PMC:7291971 / 68959-69985 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1402","span":{"begin":125,"end":129},"obj":"CHEBI:32145;CHEBI:32145"},{"id":"T1403","span":{"begin":153,"end":158},"obj":"CHEBI:30808;CHEBI:30808"},{"id":"T1404","span":{"begin":673,"end":676},"obj":"CHEBI:36927;CHEBI:36927"},{"id":"T82290","span":{"begin":125,"end":129},"obj":"CHEBI:32145;CHEBI:32145"},{"id":"T48557","span":{"begin":153,"end":158},"obj":"CHEBI:30808;CHEBI:30808"},{"id":"T48829","span":{"begin":673,"end":676},"obj":"CHEBI:36927;CHEBI:36927"}],"text":"Following method B with 29 (230 mg, 0.44 mmol, 1.00 eq), 33 (160 mg, 43%) was obtained as a pale white solid. Rf 0.52 (10:90 MeOH/DCM). 1H NMR (600 MHz, CDCl3) δ 8.29 (s, 1H), 8.28 (s, 1H), 8.116 (2s, 2H), 7.79 (s, 1H), 7.65 (dd, J = 8.4 Hz, J = 2.1 Hz, 1H), 7.39 (d, J = 8.4 Hz, 1H), 6.02–5.93 (m, 6H), 5.36 (dd, J = 6.4 Hz, J = 1.8 Hz, 1H), 5.05 (dd, J = 6.4 Hz, J = 3.8 Hz, 1H), 4.51 (dd, J = 6.1 Hz, J = 4.7 Hz, 1H), 4.44 (dt, J = 8.5 Hz, J = 4.3 Hz, 1H), 4.19 (dd, J = 4.7 Hz, J = 3.0 Hz, 1H), 4.05–3.97 (m, 2H), 3.82 (t, J = 5.5 Hz, 2H), 3.79–3.65 (m, 3H), 3.46 (q, J = 5.3 Hz, 2H), 1.56 (s, 3H), 1.35 (s, 3H), 0.92 (br. s, 9H), 0.90 (br. s, 9H), 0.12–0.05 (m, 12H). 13C NMR (150 MHz, CDCl3) δ 155.8, 155.6, 153.2, 153.1, 149.5, 149.0, 147.6, 140.3, 140.2, 139.4, 132.4, 131.3, 131.2, 124.6, 120.5, 120.2, 114.7, 90.7, 87.4, 85.0, 84.3 (2C), 82.9, 82.6, 69.7, 69.5, 61.4, 50.5, 47.7, 27.2, 26.2, 25.9, 25.4, 18.6, 18.2, −4.4, −4.7, −5.2. HRMS (ESI+): m/z calcd for C43H64N12O11SSi2Cl [M+H]+: 1047.3765, found: 1047.3766."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1213","span":{"begin":125,"end":129},"obj":"Chemical"},{"id":"1214","span":{"begin":130,"end":133},"obj":"Chemical"},{"id":"1215","span":{"begin":667,"end":670},"obj":"Chemical"},{"id":"1216","span":{"begin":971,"end":989},"obj":"Chemical"},{"id":"1217","span":{"begin":944,"end":948},"obj":"Disease"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Following method B with 29 (230 mg, 0.44 mmol, 1.00 eq), 33 (160 mg, 43%) was obtained as a pale white solid. Rf 0.52 (10:90 MeOH/DCM). 1H NMR (600 MHz, CDCl3) δ 8.29 (s, 1H), 8.28 (s, 1H), 8.116 (2s, 2H), 7.79 (s, 1H), 7.65 (dd, J = 8.4 Hz, J = 2.1 Hz, 1H), 7.39 (d, J = 8.4 Hz, 1H), 6.02–5.93 (m, 6H), 5.36 (dd, J = 6.4 Hz, J = 1.8 Hz, 1H), 5.05 (dd, J = 6.4 Hz, J = 3.8 Hz, 1H), 4.51 (dd, J = 6.1 Hz, J = 4.7 Hz, 1H), 4.44 (dt, J = 8.5 Hz, J = 4.3 Hz, 1H), 4.19 (dd, J = 4.7 Hz, J = 3.0 Hz, 1H), 4.05–3.97 (m, 2H), 3.82 (t, J = 5.5 Hz, 2H), 3.79–3.65 (m, 3H), 3.46 (q, J = 5.3 Hz, 2H), 1.56 (s, 3H), 1.35 (s, 3H), 0.92 (br. s, 9H), 0.90 (br. s, 9H), 0.12–0.05 (m, 12H). 13C NMR (150 MHz, CDCl3) δ 155.8, 155.6, 153.2, 153.1, 149.5, 149.0, 147.6, 140.3, 140.2, 139.4, 132.4, 131.3, 131.2, 124.6, 120.5, 120.2, 114.7, 90.7, 87.4, 85.0, 84.3 (2C), 82.9, 82.6, 69.7, 69.5, 61.4, 50.5, 47.7, 27.2, 26.2, 25.9, 25.4, 18.6, 18.2, −4.4, −4.7, −5.2. HRMS (ESI+): m/z calcd for C43H64N12O11SSi2Cl [M+H]+: 1047.3765, found: 1047.3766."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T385","span":{"begin":17,"end":26},"obj":"http://purl.obolibrary.org/obo/CLO_0001811"},{"id":"T386","span":{"begin":90,"end":91},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T387","span":{"begin":991,"end":994},"obj":"http://purl.obolibrary.org/obo/CLO_0007706"}],"text":"Following method B with 29 (230 mg, 0.44 mmol, 1.00 eq), 33 (160 mg, 43%) was obtained as a pale white solid. Rf 0.52 (10:90 MeOH/DCM). 1H NMR (600 MHz, CDCl3) δ 8.29 (s, 1H), 8.28 (s, 1H), 8.116 (2s, 2H), 7.79 (s, 1H), 7.65 (dd, J = 8.4 Hz, J = 2.1 Hz, 1H), 7.39 (d, J = 8.4 Hz, 1H), 6.02–5.93 (m, 6H), 5.36 (dd, J = 6.4 Hz, J = 1.8 Hz, 1H), 5.05 (dd, J = 6.4 Hz, J = 3.8 Hz, 1H), 4.51 (dd, J = 6.1 Hz, J = 4.7 Hz, 1H), 4.44 (dt, J = 8.5 Hz, J = 4.3 Hz, 1H), 4.19 (dd, J = 4.7 Hz, J = 3.0 Hz, 1H), 4.05–3.97 (m, 2H), 3.82 (t, J = 5.5 Hz, 2H), 3.79–3.65 (m, 3H), 3.46 (q, J = 5.3 Hz, 2H), 1.56 (s, 3H), 1.35 (s, 3H), 0.92 (br. s, 9H), 0.90 (br. s, 9H), 0.12–0.05 (m, 12H). 13C NMR (150 MHz, CDCl3) δ 155.8, 155.6, 153.2, 153.1, 149.5, 149.0, 147.6, 140.3, 140.2, 139.4, 132.4, 131.3, 131.2, 124.6, 120.5, 120.2, 114.7, 90.7, 87.4, 85.0, 84.3 (2C), 82.9, 82.6, 69.7, 69.5, 61.4, 50.5, 47.7, 27.2, 26.2, 25.9, 25.4, 18.6, 18.2, −4.4, −4.7, −5.2. HRMS (ESI+): m/z calcd for C43H64N12O11SSi2Cl [M+H]+: 1047.3765, found: 1047.3766."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T55220","span":{"begin":110,"end":112},"obj":"Chemical"},{"id":"T22091","span":{"begin":125,"end":129},"obj":"Chemical"},{"id":"T99475","span":{"begin":130,"end":133},"obj":"Chemical"},{"id":"T533","span":{"begin":136,"end":138},"obj":"Chemical"},{"id":"T25965","span":{"begin":153,"end":158},"obj":"Chemical"},{"id":"T39525","span":{"begin":171,"end":173},"obj":"Chemical"},{"id":"T99833","span":{"begin":185,"end":187},"obj":"Chemical"},{"id":"T64395","span":{"begin":215,"end":217},"obj":"Chemical"},{"id":"T85135","span":{"begin":254,"end":256},"obj":"Chemical"},{"id":"T18506","span":{"begin":280,"end":282},"obj":"Chemical"},{"id":"T52601","span":{"begin":338,"end":340},"obj":"Chemical"},{"id":"T78849","span":{"begin":377,"end":379},"obj":"Chemical"},{"id":"T542","span":{"begin":416,"end":418},"obj":"Chemical"},{"id":"T93066","span":{"begin":455,"end":457},"obj":"Chemical"},{"id":"T87973","span":{"begin":494,"end":496},"obj":"Chemical"},{"id":"T545","span":{"begin":691,"end":696},"obj":"Chemical"}],"attributes":[{"id":"A53329","pred":"chebi_id","subj":"T55220","obj":"http://purl.obolibrary.org/obo/CHEBI_33346"},{"id":"A23080","pred":"chebi_id","subj":"T22091","obj":"http://purl.obolibrary.org/obo/CHEBI_17790"},{"id":"A63132","pred":"chebi_id","subj":"T99475","obj":"http://purl.obolibrary.org/obo/CHEBI_15767"},{"id":"A42429","pred":"chebi_id","subj":"T533","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A13167","pred":"chebi_id","subj":"T25965","obj":"http://purl.obolibrary.org/obo/CHEBI_85365"},{"id":"A51585","pred":"chebi_id","subj":"T39525","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A70385","pred":"chebi_id","subj":"T99833","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A92536","pred":"chebi_id","subj":"T64395","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A44544","pred":"chebi_id","subj":"T85135","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A26903","pred":"chebi_id","subj":"T18506","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A4921","pred":"chebi_id","subj":"T52601","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A5046","pred":"chebi_id","subj":"T78849","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A45812","pred":"chebi_id","subj":"T542","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A36095","pred":"chebi_id","subj":"T93066","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A32972","pred":"chebi_id","subj":"T87973","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A49254","pred":"chebi_id","subj":"T545","obj":"http://purl.obolibrary.org/obo/CHEBI_85365"}],"text":"Following method B with 29 (230 mg, 0.44 mmol, 1.00 eq), 33 (160 mg, 43%) was obtained as a pale white solid. Rf 0.52 (10:90 MeOH/DCM). 1H NMR (600 MHz, CDCl3) δ 8.29 (s, 1H), 8.28 (s, 1H), 8.116 (2s, 2H), 7.79 (s, 1H), 7.65 (dd, J = 8.4 Hz, J = 2.1 Hz, 1H), 7.39 (d, J = 8.4 Hz, 1H), 6.02–5.93 (m, 6H), 5.36 (dd, J = 6.4 Hz, J = 1.8 Hz, 1H), 5.05 (dd, J = 6.4 Hz, J = 3.8 Hz, 1H), 4.51 (dd, J = 6.1 Hz, J = 4.7 Hz, 1H), 4.44 (dt, J = 8.5 Hz, J = 4.3 Hz, 1H), 4.19 (dd, J = 4.7 Hz, J = 3.0 Hz, 1H), 4.05–3.97 (m, 2H), 3.82 (t, J = 5.5 Hz, 2H), 3.79–3.65 (m, 3H), 3.46 (q, J = 5.3 Hz, 2H), 1.56 (s, 3H), 1.35 (s, 3H), 0.92 (br. s, 9H), 0.90 (br. s, 9H), 0.12–0.05 (m, 12H). 13C NMR (150 MHz, CDCl3) δ 155.8, 155.6, 153.2, 153.1, 149.5, 149.0, 147.6, 140.3, 140.2, 139.4, 132.4, 131.3, 131.2, 124.6, 120.5, 120.2, 114.7, 90.7, 87.4, 85.0, 84.3 (2C), 82.9, 82.6, 69.7, 69.5, 61.4, 50.5, 47.7, 27.2, 26.2, 25.9, 25.4, 18.6, 18.2, −4.4, −4.7, −5.2. HRMS (ESI+): m/z calcd for C43H64N12O11SSi2Cl [M+H]+: 1047.3765, found: 1047.3766."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T28","span":{"begin":130,"end":133},"obj":"Phenotype"}],"attributes":[{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0001644"}],"text":"Following method B with 29 (230 mg, 0.44 mmol, 1.00 eq), 33 (160 mg, 43%) was obtained as a pale white solid. Rf 0.52 (10:90 MeOH/DCM). 1H NMR (600 MHz, CDCl3) δ 8.29 (s, 1H), 8.28 (s, 1H), 8.116 (2s, 2H), 7.79 (s, 1H), 7.65 (dd, J = 8.4 Hz, J = 2.1 Hz, 1H), 7.39 (d, J = 8.4 Hz, 1H), 6.02–5.93 (m, 6H), 5.36 (dd, J = 6.4 Hz, J = 1.8 Hz, 1H), 5.05 (dd, J = 6.4 Hz, J = 3.8 Hz, 1H), 4.51 (dd, J = 6.1 Hz, J = 4.7 Hz, 1H), 4.44 (dt, J = 8.5 Hz, J = 4.3 Hz, 1H), 4.19 (dd, J = 4.7 Hz, J = 3.0 Hz, 1H), 4.05–3.97 (m, 2H), 3.82 (t, J = 5.5 Hz, 2H), 3.79–3.65 (m, 3H), 3.46 (q, J = 5.3 Hz, 2H), 1.56 (s, 3H), 1.35 (s, 3H), 0.92 (br. s, 9H), 0.90 (br. s, 9H), 0.12–0.05 (m, 12H). 13C NMR (150 MHz, CDCl3) δ 155.8, 155.6, 153.2, 153.1, 149.5, 149.0, 147.6, 140.3, 140.2, 139.4, 132.4, 131.3, 131.2, 124.6, 120.5, 120.2, 114.7, 90.7, 87.4, 85.0, 84.3 (2C), 82.9, 82.6, 69.7, 69.5, 61.4, 50.5, 47.7, 27.2, 26.2, 25.9, 25.4, 18.6, 18.2, −4.4, −4.7, −5.2. HRMS (ESI+): m/z calcd for C43H64N12O11SSi2Cl [M+H]+: 1047.3765, found: 1047.3766."}

{"project":"LitCovid-sentences","denotations":[{"id":"T472","span":{"begin":0,"end":109},"obj":"Sentence"},{"id":"T473","span":{"begin":110,"end":135},"obj":"Sentence"},{"id":"T474","span":{"begin":136,"end":672},"obj":"Sentence"},{"id":"T475","span":{"begin":673,"end":943},"obj":"Sentence"},{"id":"T476","span":{"begin":944,"end":997},"obj":"Sentence"},{"id":"T477","span":{"begin":998,"end":1015},"obj":"Sentence"},{"id":"T478","span":{"begin":1016,"end":1026},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Following method B with 29 (230 mg, 0.44 mmol, 1.00 eq), 33 (160 mg, 43%) was obtained as a pale white solid. Rf 0.52 (10:90 MeOH/DCM). 1H NMR (600 MHz, CDCl3) δ 8.29 (s, 1H), 8.28 (s, 1H), 8.116 (2s, 2H), 7.79 (s, 1H), 7.65 (dd, J = 8.4 Hz, J = 2.1 Hz, 1H), 7.39 (d, J = 8.4 Hz, 1H), 6.02–5.93 (m, 6H), 5.36 (dd, J = 6.4 Hz, J = 1.8 Hz, 1H), 5.05 (dd, J = 6.4 Hz, J = 3.8 Hz, 1H), 4.51 (dd, J = 6.1 Hz, J = 4.7 Hz, 1H), 4.44 (dt, J = 8.5 Hz, J = 4.3 Hz, 1H), 4.19 (dd, J = 4.7 Hz, J = 3.0 Hz, 1H), 4.05–3.97 (m, 2H), 3.82 (t, J = 5.5 Hz, 2H), 3.79–3.65 (m, 3H), 3.46 (q, J = 5.3 Hz, 2H), 1.56 (s, 3H), 1.35 (s, 3H), 0.92 (br. s, 9H), 0.90 (br. s, 9H), 0.12–0.05 (m, 12H). 13C NMR (150 MHz, CDCl3) δ 155.8, 155.6, 153.2, 153.1, 149.5, 149.0, 147.6, 140.3, 140.2, 139.4, 132.4, 131.3, 131.2, 124.6, 120.5, 120.2, 114.7, 90.7, 87.4, 85.0, 84.3 (2C), 82.9, 82.6, 69.7, 69.5, 61.4, 50.5, 47.7, 27.2, 26.2, 25.9, 25.4, 18.6, 18.2, −4.4, −4.7, −5.2. HRMS (ESI+): m/z calcd for C43H64N12O11SSi2Cl [M+H]+: 1047.3765, found: 1047.3766."}