rent viral RNA MTases which share a common Rossman fold organization [13]. The rarity of specific inhibitors for viral MTases constitutes a stimulating challenge for new antiviral therapy but also for functional studies of these fascinating enzymes.
Scheme 1 Schematic representation of the 2′-O-methylation of the cap structure at nucleoside N1 at 5′-end of mRNA to form Cap-1 RNA. General structure of compounds mimicking the 2′-O-methylation transition