PMC:7291971 / 37516-38026 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T771","span":{"begin":44,"end":63},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T772","span":{"begin":64,"end":66},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T773","span":{"begin":71,"end":74},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T774","span":{"begin":75,"end":76},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T775","span":{"begin":80,"end":81},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T776","span":{"begin":81,"end":83},"obj":"CHEBI:52029;CHEBI:52029"},{"id":"T777","span":{"begin":83,"end":96},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T778","span":{"begin":153,"end":154},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T779","span":{"begin":154,"end":172},"obj":"CHEBI:28714;CHEBI:28714"},{"id":"T780","span":{"begin":173,"end":176},"obj":"CHEBI:29354;CHEBI:29354"},{"id":"T781","span":{"begin":177,"end":181},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T782","span":{"begin":182,"end":188},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T783","span":{"begin":188,"end":206},"obj":"CHEBI:8502;CHEBI:8502"},{"id":"T784","span":{"begin":206,"end":207},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T785","span":{"begin":207,"end":210},"obj":"CHEBI:29354;CHEBI:29354"},{"id":"T786","span":{"begin":211,"end":217},"obj":"CHEBI:16625;CHEBI:16625"},{"id":"T787","span":{"begin":218,"end":230},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T788","span":{"begin":230,"end":233},"obj":"CHEBI:15533;CHEBI:15533"},{"id":"T789","span":{"begin":240,"end":243},"obj":"CHEBI:86228;CHEBI:86228"},{"id":"T790","span":{"begin":243,"end":255},"obj":"CHEBI:27798;CHEBI:27798"},{"id":"T791","span":{"begin":255,"end":258},"obj":"CHEBI:86228;CHEBI:86228"},{"id":"T792","span":{"begin":258,"end":269},"obj":"CHEBI:35358;CHEBI:35358"},{"id":"T793","span":{"begin":402,"end":406},"obj":"CHEBI:32145;CHEBI:32145"},{"id":"T794","span":{"begin":430,"end":435},"obj":"CHEBI:30808;CHEBI:30808"},{"id":"T68367","span":{"begin":44,"end":63},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T40445","span":{"begin":64,"end":66},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T4224","span":{"begin":71,"end":74},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T91423","span":{"begin":75,"end":76},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T12675","span":{"begin":80,"end":81},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T79796","span":{"begin":81,"end":83},"obj":"CHEBI:52029;CHEBI:52029"},{"id":"T73827","span":{"begin":83,"end":96},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T62607","span":{"begin":153,"end":154},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T53578","span":{"begin":154,"end":172},"obj":"CHEBI:28714;CHEBI:28714"},{"id":"T64666","span":{"begin":173,"end":176},"obj":"CHEBI:29354;CHEBI:29354"},{"id":"T28006","span":{"begin":177,"end":181},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T25194","span":{"begin":182,"end":188},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T51661","span":{"begin":188,"end":206},"obj":"CHEBI:8502;CHEBI:8502"},{"id":"T35859","span":{"begin":206,"end":207},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T59756","span":{"begin":207,"end":210},"obj":"CHEBI:29354;CHEBI:29354"},{"id":"T74145","span":{"begin":211,"end":217},"obj":"CHEBI:16625;CHEBI:16625"},{"id":"T18351","span":{"begin":218,"end":230},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T71610","span":{"begin":230,"end":233},"obj":"CHEBI:15533;CHEBI:15533"},{"id":"T27362","span":{"begin":240,"end":243},"obj":"CHEBI:86228;CHEBI:86228"},{"id":"T98530","span":{"begin":243,"end":255},"obj":"CHEBI:27798;CHEBI:27798"},{"id":"T56202","span":{"begin":255,"end":258},"obj":"CHEBI:86228;CHEBI:86228"},{"id":"T15954","span":{"begin":258,"end":269},"obj":"CHEBI:35358;CHEBI:35358"},{"id":"T27636","span":{"begin":402,"end":406},"obj":"CHEBI:32145;CHEBI:32145"},{"id":"T70470","span":{"begin":430,"end":435},"obj":"CHEBI:30808;CHEBI:30808"}],"text":" N-{[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}-N-(2-{[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-3-yl]oxy}ethyl)-4-nitrobenzene-1-sulfonamide (19)\nFollowing method B using 18 (290 mg, 0.59 mmol, 1.00 eq), 19 (450 mg, 74%) was obtained as a pale yellow solid. Rf 0.60 (10:90 MeOH/DCM). 1H NMR (600 MHz, CDCl3) δ 8.30 (2s, 2H), 8.14 (s, 1H), 8.03–7.98 (m, 2H), 7.74 (s, 1H), 7.70–7.66"}

{"project":"LitCovid-PubTator","denotations":[{"id":"656","span":{"begin":402,"end":406},"obj":"Chemical"},{"id":"657","span":{"begin":407,"end":410},"obj":"Chemical"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":" N-{[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}-N-(2-{[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-3-yl]oxy}ethyl)-4-nitrobenzene-1-sulfonamide (19)\nFollowing method B using 18 (290 mg, 0.59 mmol, 1.00 eq), 19 (450 mg, 74%) was obtained as a pale yellow solid. Rf 0.60 (10:90 MeOH/DCM). 1H NMR (600 MHz, CDCl3) δ 8.30 (2s, 2H), 8.14 (s, 1H), 8.03–7.98 (m, 2H), 7.74 (s, 1H), 7.70–7.66"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T282","span":{"begin":292,"end":293},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T283","span":{"begin":300,"end":302},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T284","span":{"begin":366,"end":367},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":" N-{[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}-N-(2-{[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-3-yl]oxy}ethyl)-4-nitrobenzene-1-sulfonamide (19)\nFollowing method B using 18 (290 mg, 0.59 mmol, 1.00 eq), 19 (450 mg, 74%) was obtained as a pale yellow solid. Rf 0.60 (10:90 MeOH/DCM). 1H NMR (600 MHz, CDCl3) δ 8.30 (2s, 2H), 8.14 (s, 1H), 8.03–7.98 (m, 2H), 7.74 (s, 1H), 7.70–7.66"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T626","span":{"begin":17,"end":38},"obj":"Chemical"},{"id":"T627","span":{"begin":19,"end":24},"obj":"Chemical"},{"id":"T628","span":{"begin":44,"end":52},"obj":"Chemical"},{"id":"T630","span":{"begin":96,"end":102},"obj":"Chemical"},{"id":"T632","span":{"begin":122,"end":143},"obj":"Chemical"},{"id":"T633","span":{"begin":124,"end":129},"obj":"Chemical"},{"id":"T634","span":{"begin":173,"end":176},"obj":"Chemical"},{"id":"T635","span":{"begin":207,"end":210},"obj":"Chemical"},{"id":"T636","span":{"begin":211,"end":217},"obj":"Chemical"},{"id":"T638","span":{"begin":230,"end":233},"obj":"Chemical"},{"id":"T639","span":{"begin":234,"end":239},"obj":"Chemical"},{"id":"T641","span":{"begin":243,"end":255},"obj":"Chemical"},{"id":"T642","span":{"begin":258,"end":269},"obj":"Chemical"},{"id":"T643","span":{"begin":387,"end":389},"obj":"Chemical"},{"id":"T644","span":{"begin":402,"end":406},"obj":"Chemical"},{"id":"T645","span":{"begin":407,"end":410},"obj":"Chemical"},{"id":"T646","span":{"begin":413,"end":415},"obj":"Chemical"},{"id":"T647","span":{"begin":430,"end":435},"obj":"Chemical"},{"id":"T648","span":{"begin":463,"end":465},"obj":"Chemical"},{"id":"T649","span":{"begin":496,"end":498},"obj":"Chemical"}],"attributes":[{"id":"A626","pred":"chebi_id","subj":"T626","obj":"http://purl.obolibrary.org/obo/CHEBI_30756"},{"id":"A627","pred":"chebi_id","subj":"T627","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A628","pred":"chebi_id","subj":"T628","obj":"http://purl.obolibrary.org/obo/CHEBI_33601"},{"id":"A629","pred":"chebi_id","subj":"T628","obj":"http://purl.obolibrary.org/obo/CHEBI_42266"},{"id":"A630","pred":"chebi_id","subj":"T630","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A631","pred":"chebi_id","subj":"T630","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A632","pred":"chebi_id","subj":"T632","obj":"http://purl.obolibrary.org/obo/CHEBI_30756"},{"id":"A633","pred":"chebi_id","subj":"T633","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A634","pred":"chebi_id","subj":"T634","obj":"http://purl.obolibrary.org/obo/CHEBI_29354"},{"id":"A635","pred":"chebi_id","subj":"T635","obj":"http://purl.obolibrary.org/obo/CHEBI_29354"},{"id":"A636","pred":"chebi_id","subj":"T636","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A637","pred":"chebi_id","subj":"T636","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A638","pred":"chebi_id","subj":"T638","obj":"http://purl.obolibrary.org/obo/CHEBI_29354"},{"id":"A639","pred":"chebi_id","subj":"T639","obj":"http://purl.obolibrary.org/obo/CHEBI_37807"},{"id":"A640","pred":"chebi_id","subj":"T639","obj":"http://purl.obolibrary.org/obo/CHEBI_62801"},{"id":"A641","pred":"chebi_id","subj":"T641","obj":"http://purl.obolibrary.org/obo/CHEBI_27798"},{"id":"A642","pred":"chebi_id","subj":"T642","obj":"http://purl.obolibrary.org/obo/CHEBI_35358"},{"id":"A643","pred":"chebi_id","subj":"T643","obj":"http://purl.obolibrary.org/obo/CHEBI_33346"},{"id":"A644","pred":"chebi_id","subj":"T644","obj":"http://purl.obolibrary.org/obo/CHEBI_17790"},{"id":"A645","pred":"chebi_id","subj":"T645","obj":"http://purl.obolibrary.org/obo/CHEBI_15767"},{"id":"A646","pred":"chebi_id","subj":"T646","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A647","pred":"chebi_id","subj":"T647","obj":"http://purl.obolibrary.org/obo/CHEBI_85365"},{"id":"A648","pred":"chebi_id","subj":"T648","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A649","pred":"chebi_id","subj":"T649","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"}],"text":" N-{[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}-N-(2-{[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-3-yl]oxy}ethyl)-4-nitrobenzene-1-sulfonamide (19)\nFollowing method B using 18 (290 mg, 0.59 mmol, 1.00 eq), 19 (450 mg, 74%) was obtained as a pale yellow solid. Rf 0.60 (10:90 MeOH/DCM). 1H NMR (600 MHz, CDCl3) δ 8.30 (2s, 2H), 8.14 (s, 1H), 8.03–7.98 (m, 2H), 7.74 (s, 1H), 7.70–7.66"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T6","span":{"begin":407,"end":410},"obj":"Phenotype"}],"attributes":[{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0001644"}],"text":" N-{[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}-N-(2-{[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-3-yl]oxy}ethyl)-4-nitrobenzene-1-sulfonamide (19)\nFollowing method B using 18 (290 mg, 0.59 mmol, 1.00 eq), 19 (450 mg, 74%) was obtained as a pale yellow solid. Rf 0.60 (10:90 MeOH/DCM). 1H NMR (600 MHz, CDCl3) δ 8.30 (2s, 2H), 8.14 (s, 1H), 8.03–7.98 (m, 2H), 7.74 (s, 1H), 7.70–7.66"}

{"project":"LitCovid-sentences","denotations":[{"id":"T280","span":{"begin":275,"end":386},"obj":"Sentence"},{"id":"T281","span":{"begin":387,"end":412},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" N-{[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}-N-(2-{[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-3-yl]oxy}ethyl)-4-nitrobenzene-1-sulfonamide (19)\nFollowing method B using 18 (290 mg, 0.59 mmol, 1.00 eq), 19 (450 mg, 74%) was obtained as a pale yellow solid. Rf 0.60 (10:90 MeOH/DCM). 1H NMR (600 MHz, CDCl3) δ 8.30 (2s, 2H), 8.14 (s, 1H), 8.03–7.98 (m, 2H), 7.74 (s, 1H), 7.70–7.66"}