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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7291971","sourcedb":"PMC","sourceid":"7291971","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7291971","text":"Table 2 Comparison of IC50 values of 10 most active compounds on SARS-CoV nsp14 and human RNMT activities.\nCompounds SARS-CoV nsp14 IC50a (μM) hRNMTIC50 (μM)\nSinefunginb 0.36 \u003c0.05\n2 40.6 ± 3.2 10.9 ± 1.0\n6 55.5 ± 5.1 \u003e500\n9 2.6 ± 0.2 \u003e500\n10 3.9 ± 0.4 \u003e500\n11 70.4 ± 4.9 169.3 ± 30.4\n12 5.7 ± 0.5 275.9 ± 28.7\n13 0.6 ± 0.1 247.5 ± 14.9\n14 1.5 ± 0.1 n.d\n15 2.4 ± 0.2 n.i\n16 9.9 ± 0.9 n.d\na Concentration inhibiting MTase activity by 50%; mean value from three independent experiments.\nb values from the literature [11]. The MTase activity for IC50 determinations was measured using a filter binding assay as described above. n.i: no inhibition detected at 50 μM; n.d: not determined due to inhibition lower than 50% at 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