ent and specific inhibitor of SARS-CoV nsp14 N7-methyltransferase. • Molecular docking and biophysical assays corroborated observed SAR. 1 Introduction Emerging RNA viruses are serious threats to public health and have become a worldwide concern. The violent Ebola virus crisis in 2014 [1] (case fatality rate ≈ 50%) and the recurrent outbreaks of Coronaviruses in 2003 (SARS-CoV