Previous studies regarding SARS and MERS indicated that approximately 60% of patients presented with hepatopathy, mostly in the form of elevated liver enzymes [13]. Severe COVID-19 disease has been associated with a high prevalence of abnormal aminotransferase levels; however, they may also be of non-hepatic origin [12]. We aimed to systematically review the existing data to determine the correlation of hepatic involvement in patients with either SARS-CoV-1, MERS-CoV or SARS-CoV-2 infection, and determine a relationship with outcomes, especially prognosis in patients with COVID-19.