n of type I IFN genes [184,185,186]. Therefore, PEDV nsp1 blocks type I IFN production in the nucleus. Activated NF-κB induces the production of type I IFNs and proinflammatory cytokines and is important for inhibiting viral infection. PEDV nsp1 has been shown to interfere with the NF-κB activity [78] and is the most potent suppressor of proinflammatory cy