Fifty-eight IAV whole genome sequences were retrieved from Mexican swine during 2010–2014. Genome sequence analysis identified classical H1N1, H3N2, and A(H1N1)pdm09 viruses. Interestingly, the data obtained in this study suggested independent evolution of IAV in the Mexican swine population in different regions of the country. Phylogeny determined that Mexico City was the source of the 2009 influenza pandemic which erupted during March–May 2009 [33]. Later a reassortant H1N2 virus which had the genes from human and swine influenza viruses was isolated and sequenced from a swine in November 2014 [309].