The Minnesota Veterinary Diagnostic Laboratory (MVDL) detected large number of H1N1, H1N2 and H3N2 subtypes of IAV in swine samples during 1998–2001 and again during 2007–2009. Interestingly, some of the samples were co-infected with H1N1 and H3N2 viruses [269,270,271]. A second-generation reassortant H1N2 virus having genes from a reassortant H3N2 and classical H1 swine influenza viruses was obtained from the lung tissue samples of a dead sow at an Indiana swine farm in November 1999 [272].