The IAV was first isolated from the nasal discharge of a swine in the United States in 1931 [34] and from the human in 1933 [35]. The first report of human-origin IAV in swine appeared in the United States on 24 May 1937 after an unexpected result was observed when the serum sample of a sick swine obtained from a State Prison Farm located in New Jersey neutralized the antibodies of human influenza virus. A series of investigations made a strikingly new observation that swine had suffered from a human strain of influenza virus [259].