Among four types of the influenza viruses, IAV is the most prevalent type and has been reported in swine in several countries. The IAV was first isolated from the nasal discharge of a swine in 1931 [34] and from the human in 1933 [35]. Strains of IAV have been reported to cause mild to severe upper respiratory tract illness in swine [36]. Strains of Victoria/B and Yamagata/B lineages of IBV were first reported in swine in the United States in 2010 [37] while the ICV in swine was first isolated in China in 1983 [38]. Both, the IBV and ICV cause mild respiratory illness in swine [39,40,41,42]. The IDV in swine was first detected in Oklahoma based swine in the United States in 2011 [5,43] which in later years has been detected in swine in China [44], Italy [45] and Luxembourg [46]. Interestingly, influenza viruses can be detected in the swine throughout the year unlike humans where seasonality affects the occurrence and progression of the disease [47,48].