Shortly after a respiratory disease outbreak in swine in Manitoba, an autopsy was done on a dead swine on March 1, 1967. The histopathology confirmed the bronchitis in the deceased swine and a strain of IAV designated as “S/Manitoba/647/67” was characterized using IAV antisera [234]. The first report of H1N1 virus in Canadian swine appeared in Quebec during 1980s–1990s when five genotypes of H1N1 virus were identified [235]. Since then several studies have reported H1N1, H1N2 and H3N2 viruses in Canadian swine [236,237,238,239,240,241,242,243].