PMC:7279430 / 27034-27431 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T78","span":{"begin":255,"end":265},"obj":"Body_part"}],"attributes":[{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma82739"}],"text":"Lowest-energy docked poses of (E)-β-farnesene and (E,E)-α-farnesene with the SARS-CoV-2 main protease (PDB: 6LU7). (A) Ribbon structure of the enzyme and (E)-β-farnesene. (B) Solid structure of the enzyme showing (E)-β-farnesene in the binding cleft. (C) Amino acid residues in proximity to the docked (E)-β-farnesene. (D) Lowest-energy docked pose of (E,E)-α-farnesene in the enzyme binding site."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1569","span":{"begin":53,"end":57},"obj":"Species"},{"id":"1570","span":{"begin":77,"end":87},"obj":"Species"},{"id":"1571","span":{"begin":355,"end":359},"obj":"Species"},{"id":"1572","span":{"begin":30,"end":45},"obj":"Chemical"},{"id":"1573","span":{"begin":154,"end":169},"obj":"Chemical"},{"id":"1574","span":{"begin":213,"end":228},"obj":"Chemical"},{"id":"1575","span":{"begin":306,"end":317},"obj":"Chemical"}],"attributes":[{"id":"A1569","pred":"tao:has_database_id","subj":"1569","obj":"Tax:114629"},{"id":"A1570","pred":"tao:has_database_id","subj":"1570","obj":"Tax:2697049"},{"id":"A1571","pred":"tao:has_database_id","subj":"1571","obj":"Tax:114629"},{"id":"A1575","pred":"tao:has_database_id","subj":"1575","obj":"MESH:C062671"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Lowest-energy docked poses of (E)-β-farnesene and (E,E)-α-farnesene with the SARS-CoV-2 main protease (PDB: 6LU7). (A) Ribbon structure of the enzyme and (E)-β-farnesene. (B) Solid structure of the enzyme showing (E)-β-farnesene in the binding cleft. (C) Amino acid residues in proximity to the docked (E)-β-farnesene. (D) Lowest-energy docked pose of (E,E)-α-farnesene in the enzyme binding site."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T159","span":{"begin":77,"end":85},"obj":"Disease"}],"attributes":[{"id":"A159","pred":"mondo_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Lowest-energy docked poses of (E)-β-farnesene and (E,E)-α-farnesene with the SARS-CoV-2 main protease (PDB: 6LU7). (A) Ribbon structure of the enzyme and (E)-β-farnesene. (B) Solid structure of the enzyme showing (E)-β-farnesene in the binding cleft. (C) Amino acid residues in proximity to the docked (E)-β-farnesene. (D) Lowest-energy docked pose of (E,E)-α-farnesene in the enzyme binding site."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T213","span":{"begin":116,"end":117},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T214","span":{"begin":172,"end":173},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T215","span":{"begin":255,"end":274},"obj":"http://purl.obolibrary.org/obo/CHEBI_33708"},{"id":"T216","span":{"begin":255,"end":274},"obj":"http://purl.obolibrary.org/obo/PR_000036907"}],"text":"Lowest-energy docked poses of (E)-β-farnesene and (E,E)-α-farnesene with the SARS-CoV-2 main protease (PDB: 6LU7). (A) Ribbon structure of the enzyme and (E)-β-farnesene. (B) Solid structure of the enzyme showing (E)-β-farnesene in the binding cleft. (C) Amino acid residues in proximity to the docked (E)-β-farnesene. (D) Lowest-energy docked pose of (E,E)-α-farnesene in the enzyme binding site."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T413","span":{"begin":36,"end":45},"obj":"Chemical"},{"id":"T414","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T415","span":{"begin":160,"end":169},"obj":"Chemical"},{"id":"T416","span":{"begin":219,"end":228},"obj":"Chemical"},{"id":"T417","span":{"begin":255,"end":265},"obj":"Chemical"},{"id":"T418","span":{"begin":261,"end":265},"obj":"Chemical"},{"id":"T419","span":{"begin":308,"end":317},"obj":"Chemical"},{"id":"T420","span":{"begin":360,"end":369},"obj":"Chemical"}],"attributes":[{"id":"A413","pred":"chebi_id","subj":"T413","obj":"http://purl.obolibrary.org/obo/CHEBI_39237"},{"id":"A414","pred":"chebi_id","subj":"T414","obj":"http://purl.obolibrary.org/obo/CHEBI_39237"},{"id":"A415","pred":"chebi_id","subj":"T415","obj":"http://purl.obolibrary.org/obo/CHEBI_39237"},{"id":"A416","pred":"chebi_id","subj":"T416","obj":"http://purl.obolibrary.org/obo/CHEBI_39237"},{"id":"A417","pred":"chebi_id","subj":"T417","obj":"http://purl.obolibrary.org/obo/CHEBI_33704"},{"id":"A418","pred":"chebi_id","subj":"T418","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A419","pred":"chebi_id","subj":"T419","obj":"http://purl.obolibrary.org/obo/CHEBI_39237"},{"id":"A420","pred":"chebi_id","subj":"T420","obj":"http://purl.obolibrary.org/obo/CHEBI_39237"}],"text":"Lowest-energy docked poses of (E)-β-farnesene and (E,E)-α-farnesene with the SARS-CoV-2 main protease (PDB: 6LU7). (A) Ribbon structure of the enzyme and (E)-β-farnesene. (B) Solid structure of the enzyme showing (E)-β-farnesene in the binding cleft. (C) Amino acid residues in proximity to the docked (E)-β-farnesene. (D) Lowest-energy docked pose of (E,E)-α-farnesene in the enzyme binding site."}

{"project":"LitCovid-sentences","denotations":[{"id":"T223","span":{"begin":108,"end":397},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Lowest-energy docked poses of (E)-β-farnesene and (E,E)-α-farnesene with the SARS-CoV-2 main protease (PDB: 6LU7). (A) Ribbon structure of the enzyme and (E)-β-farnesene. (B) Solid structure of the enzyme showing (E)-β-farnesene in the binding cleft. (C) Amino acid residues in proximity to the docked (E)-β-farnesene. (D) Lowest-energy docked pose of (E,E)-α-farnesene in the enzyme binding site."}