PMC:7279430 / 19637-20300 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T47","span":{"begin":67,"end":74},"obj":"Body_part"},{"id":"T48","span":{"begin":233,"end":241},"obj":"Body_part"}],"attributes":[{"id":"A47","pred":"fma_id","subj":"T47","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A48","pred":"fma_id","subj":"T48","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Based on the docking energies of essential oil components with key protein targets of SARS-CoV-2, the individual essential oil components cannot be considered viable chemotherapeutic agents for interaction with the SARS-CoV-2 target proteins. However, essential oils are complex mixtures of compounds and several essential oil components may act synergistically to inhibit the virus. Astani and co-workers have shown, for example, that the antiviral activity (HSV-1) of Eucalyptus oil is much greater than the major component 1,8-cineole, and that tea tree oil has a greater antiviral activity than its components terpinen-4-ol, γ-terpinene, and α-terpinene [52]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"821","span":{"begin":86,"end":96},"obj":"Species"},{"id":"822","span":{"begin":215,"end":225},"obj":"Species"},{"id":"823","span":{"begin":460,"end":465},"obj":"Species"},{"id":"824","span":{"begin":548,"end":556},"obj":"Species"},{"id":"825","span":{"begin":470,"end":480},"obj":"Species"},{"id":"826","span":{"begin":33,"end":46},"obj":"Chemical"},{"id":"827","span":{"begin":113,"end":126},"obj":"Chemical"},{"id":"828","span":{"begin":252,"end":266},"obj":"Chemical"},{"id":"829","span":{"begin":313,"end":326},"obj":"Chemical"},{"id":"830","span":{"begin":526,"end":537},"obj":"Chemical"},{"id":"831","span":{"begin":614,"end":627},"obj":"Chemical"},{"id":"832","span":{"begin":629,"end":640},"obj":"Chemical"},{"id":"833","span":{"begin":646,"end":657},"obj":"Chemical"}],"attributes":[{"id":"A821","pred":"tao:has_database_id","subj":"821","obj":"Tax:2697049"},{"id":"A822","pred":"tao:has_database_id","subj":"822","obj":"Tax:2697049"},{"id":"A823","pred":"tao:has_database_id","subj":"823","obj":"Tax:10298"},{"id":"A824","pred":"tao:has_database_id","subj":"824","obj":"Tax:164405"},{"id":"A825","pred":"tao:has_database_id","subj":"825","obj":"Tax:34317"},{"id":"A826","pred":"tao:has_database_id","subj":"826","obj":"MESH:D009822"},{"id":"A827","pred":"tao:has_database_id","subj":"827","obj":"MESH:D009822"},{"id":"A828","pred":"tao:has_database_id","subj":"828","obj":"MESH:D009822"},{"id":"A829","pred":"tao:has_database_id","subj":"829","obj":"MESH:D009822"},{"id":"A830","pred":"tao:has_database_id","subj":"830","obj":"MESH:D000077591"},{"id":"A831","pred":"tao:has_database_id","subj":"831","obj":"MESH:C034019"},{"id":"A832","pred":"tao:has_database_id","subj":"832","obj":"MESH:C018669"},{"id":"A833","pred":"tao:has_database_id","subj":"833","obj":"MESH:C018669"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Based on the docking energies of essential oil components with key protein targets of SARS-CoV-2, the individual essential oil components cannot be considered viable chemotherapeutic agents for interaction with the SARS-CoV-2 target proteins. However, essential oils are complex mixtures of compounds and several essential oil components may act synergistically to inhibit the virus. Astani and co-workers have shown, for example, that the antiviral activity (HSV-1) of Eucalyptus oil is much greater than the major component 1,8-cineole, and that tea tree oil has a greater antiviral activity than its components terpinen-4-ol, γ-terpinene, and α-terpinene [52]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T116","span":{"begin":86,"end":94},"obj":"Disease"},{"id":"T117","span":{"begin":215,"end":223},"obj":"Disease"}],"attributes":[{"id":"A116","pred":"mondo_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A117","pred":"mondo_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Based on the docking energies of essential oil components with key protein targets of SARS-CoV-2, the individual essential oil components cannot be considered viable chemotherapeutic agents for interaction with the SARS-CoV-2 target proteins. However, essential oils are complex mixtures of compounds and several essential oil components may act synergistically to inhibit the virus. Astani and co-workers have shown, for example, that the antiviral activity (HSV-1) of Eucalyptus oil is much greater than the major component 1,8-cineole, and that tea tree oil has a greater antiviral activity than its components terpinen-4-ol, γ-terpinene, and α-terpinene [52]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T138","span":{"begin":377,"end":382},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T139","span":{"begin":450,"end":458},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T140","span":{"begin":561,"end":564},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T141","span":{"begin":565,"end":566},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T142","span":{"begin":585,"end":593},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T143","span":{"begin":659,"end":661},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"}],"text":"Based on the docking energies of essential oil components with key protein targets of SARS-CoV-2, the individual essential oil components cannot be considered viable chemotherapeutic agents for interaction with the SARS-CoV-2 target proteins. However, essential oils are complex mixtures of compounds and several essential oil components may act synergistically to inhibit the virus. Astani and co-workers have shown, for example, that the antiviral activity (HSV-1) of Eucalyptus oil is much greater than the major component 1,8-cineole, and that tea tree oil has a greater antiviral activity than its components terpinen-4-ol, γ-terpinene, and α-terpinene [52]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T310","span":{"begin":33,"end":57},"obj":"Chemical"},{"id":"T311","span":{"begin":33,"end":46},"obj":"Chemical"},{"id":"T312","span":{"begin":67,"end":74},"obj":"Chemical"},{"id":"T313","span":{"begin":113,"end":137},"obj":"Chemical"},{"id":"T314","span":{"begin":113,"end":126},"obj":"Chemical"},{"id":"T315","span":{"begin":233,"end":241},"obj":"Chemical"},{"id":"T316","span":{"begin":252,"end":266},"obj":"Chemical"},{"id":"T317","span":{"begin":313,"end":337},"obj":"Chemical"},{"id":"T318","span":{"begin":313,"end":326},"obj":"Chemical"},{"id":"T319","span":{"begin":440,"end":449},"obj":"Chemical"},{"id":"T320","span":{"begin":526,"end":537},"obj":"Chemical"},{"id":"T321","span":{"begin":530,"end":537},"obj":"Chemical"},{"id":"T322","span":{"begin":548,"end":560},"obj":"Chemical"},{"id":"T323","span":{"begin":575,"end":584},"obj":"Chemical"}],"attributes":[{"id":"A310","pred":"chebi_id","subj":"T310","obj":"http://purl.obolibrary.org/obo/CHEBI_27311"},{"id":"A311","pred":"chebi_id","subj":"T311","obj":"http://purl.obolibrary.org/obo/CHEBI_83630"},{"id":"A312","pred":"chebi_id","subj":"T312","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A313","pred":"chebi_id","subj":"T313","obj":"http://purl.obolibrary.org/obo/CHEBI_27311"},{"id":"A314","pred":"chebi_id","subj":"T314","obj":"http://purl.obolibrary.org/obo/CHEBI_83630"},{"id":"A315","pred":"chebi_id","subj":"T315","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A316","pred":"chebi_id","subj":"T316","obj":"http://purl.obolibrary.org/obo/CHEBI_83630"},{"id":"A317","pred":"chebi_id","subj":"T317","obj":"http://purl.obolibrary.org/obo/CHEBI_27311"},{"id":"A318","pred":"chebi_id","subj":"T318","obj":"http://purl.obolibrary.org/obo/CHEBI_83630"},{"id":"A319","pred":"chebi_id","subj":"T319","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A320","pred":"chebi_id","subj":"T320","obj":"http://purl.obolibrary.org/obo/CHEBI_27961"},{"id":"A321","pred":"chebi_id","subj":"T321","obj":"http://purl.obolibrary.org/obo/CHEBI_23243"},{"id":"A322","pred":"chebi_id","subj":"T322","obj":"http://purl.obolibrary.org/obo/CHEBI_83629"},{"id":"A323","pred":"chebi_id","subj":"T323","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"}],"text":"Based on the docking energies of essential oil components with key protein targets of SARS-CoV-2, the individual essential oil components cannot be considered viable chemotherapeutic agents for interaction with the SARS-CoV-2 target proteins. However, essential oils are complex mixtures of compounds and several essential oil components may act synergistically to inhibit the virus. Astani and co-workers have shown, for example, that the antiviral activity (HSV-1) of Eucalyptus oil is much greater than the major component 1,8-cineole, and that tea tree oil has a greater antiviral activity than its components terpinen-4-ol, γ-terpinene, and α-terpinene [52]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T14","span":{"begin":67,"end":82},"obj":"http://purl.obolibrary.org/obo/GO_0006605"}],"text":"Based on the docking energies of essential oil components with key protein targets of SARS-CoV-2, the individual essential oil components cannot be considered viable chemotherapeutic agents for interaction with the SARS-CoV-2 target proteins. However, essential oils are complex mixtures of compounds and several essential oil components may act synergistically to inhibit the virus. Astani and co-workers have shown, for example, that the antiviral activity (HSV-1) of Eucalyptus oil is much greater than the major component 1,8-cineole, and that tea tree oil has a greater antiviral activity than its components terpinen-4-ol, γ-terpinene, and α-terpinene [52]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T130","span":{"begin":0,"end":242},"obj":"Sentence"},{"id":"T131","span":{"begin":243,"end":383},"obj":"Sentence"},{"id":"T132","span":{"begin":384,"end":663},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Based on the docking energies of essential oil components with key protein targets of SARS-CoV-2, the individual essential oil components cannot be considered viable chemotherapeutic agents for interaction with the SARS-CoV-2 target proteins. However, essential oils are complex mixtures of compounds and several essential oil components may act synergistically to inhibit the virus. Astani and co-workers have shown, for example, that the antiviral activity (HSV-1) of Eucalyptus oil is much greater than the major component 1,8-cineole, and that tea tree oil has a greater antiviral activity than its components terpinen-4-ol, γ-terpinene, and α-terpinene [52]."}