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PMC:7279430 / 11939-21098 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T13 34-42 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T14 247-254 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T15 438-441 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T16 452-455 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T17 529-536 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 1304-1312 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T19 1413-1416 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T20 2325-2332 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T21 2409-2412 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T22 2843-2853 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T23 3265-3272 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T24 4530-4533 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T25 4544-4547 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T26 4569-4572 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T27 4593-4596 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T28 4636-4639 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T29 4997-5004 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T30 5077-5081 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T31 5569-5576 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T32 5851-5858 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 5859-5866 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T34 5908-5915 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T35 5945-5949 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T36 6202-6209 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T37 6263-6270 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T38 6628-6636 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T39 6704-6712 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T40 6737-6744 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T41 6951-6953 Body_part denotes A2 http://purl.org/sig/ont/fma/fma66595
T42 7072-7080 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T43 7191-7199 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T44 7359-7367 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T45 7652-7660 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T46 7688-7696 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T47 7765-7772 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48 7931-7939 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 1835-1843 Body_part denotes mol), (E http://purl.obolibrary.org/obo/UBERON_1000010
T4 2628-2636 Body_part denotes mol), (E http://purl.obolibrary.org/obo/UBERON_1000010
T5 2670-2678 Body_part denotes mol), (E http://purl.obolibrary.org/obo/UBERON_1000010
T6 4007-4015 Body_part denotes mol), (E http://purl.obolibrary.org/obo/UBERON_1000010
T7 5945-5949 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T8 6042-6050 Body_part denotes mol; (E) http://purl.obolibrary.org/obo/UBERON_1000010

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
464 308-312 Gene denotes Mpro Gene:8673700
465 479-483 Gene denotes RdRp Gene:43740578
466 523-528 Gene denotes spike Gene:43740568
467 564-593 Gene denotes angiotensin−converting enzyme Gene:1636
468 595-600 Gene denotes hACE2 Gene:59272
469 789-793 Gene denotes Mpro Gene:8673700
470 68-115 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
471 117-127 Species denotes SARS-CoV-2 Tax:2697049
472 271-281 Species denotes SARS-CoV-2 Tax:2697049
473 297-307 Species denotes SARS-CoV-2 Tax:2697049
474 315-325 Species denotes SARS-CoV-2 Tax:2697049
475 345-355 Species denotes SARS-CoV-2 Tax:2697049
476 371-381 Species denotes SARS-CoV-2 Tax:2697049
477 409-419 Species denotes SARS-CoV-2 Tax:2697049
478 427-437 Species denotes SARS-CoV-2 Tax:2697049
479 468-478 Species denotes SARS-CoV-2 Tax:2697049
480 512-522 Species denotes SARS-CoV-2 Tax:2697049
481 538-548 Species denotes SARS-CoV-2 Tax:2697049
482 558-563 Species denotes human Tax:9606
483 778-788 Species denotes SARS-CoV-2 Tax:2697049
484 204-228 Disease denotes coronavirus disease 2019 MESH:C000657245
485 230-238 Disease denotes COVID-19 MESH:C000657245
493 1007-1011 Gene denotes Mpro Gene:8673700
494 1194-1198 Gene denotes RdRp Gene:43740578
495 996-1006 Species denotes SARS-CoV-2 Tax:2697049
496 1077-1087 Species denotes SARS-CoV-2 Tax:2697049
497 1130-1140 Species denotes SARS-CoV-2 Tax:2697049
498 1183-1193 Species denotes SARS-CoV-2 Tax:2697049
499 1114-1117 CellLine denotes W01 CVCL:6008
537 1293-1297 Gene denotes Mpro Gene:8673700
538 1787-1791 Gene denotes Mpro Gene:8673700
539 1631-1635 Gene denotes Mpro Gene:8673700
540 1282-1292 Species denotes SARS-CoV-2 Tax:2697049
541 1401-1412 Species denotes coronavirus Tax:11118
542 1620-1630 Species denotes SARS-CoV-2 Tax:2697049
543 1776-1786 Species denotes SARS-CoV-2 Tax:2697049
544 1800-1804 Species denotes E)-α Tax:114629
545 1960-1964 Species denotes E)-α Tax:114629
546 1487-1493 Chemical denotes Gln189
547 1495-1500 Chemical denotes Met49
548 1502-1508 Chemical denotes Pro168
549 1510-1516 Chemical denotes Glu166
550 1521-1526 Chemical denotes His41
551 1547-1553 Chemical denotes Cys145
552 1558-1563 Chemical denotes His41
553 1644-1669 Chemical denotes sesquiterpene hydrocarbon
554 1670-1685 Chemical denotes (E)-β-farnesene
555 1718-1731 Chemical denotes essential oil MESH:D009822
556 1841-1855 Chemical denotes (E,E)-farnesol
557 1886-1899 Chemical denotes (E)-nerolidol
558 1930-1956 Chemical denotes sesquiterpene hydrocarbons
559 1979-1994 Chemical denotes (E)-β-farnesene
560 2041-2047 Chemical denotes Gln189
561 2049-2055 Chemical denotes Arg188
562 2057-2063 Chemical denotes Met165
563 2065-2070 Chemical denotes His41
564 2076-2079 Chemical denotes Asp MESH:D001224
565 2135-2149 Chemical denotes (E,E)-farnesol
566 2154-2167 Chemical denotes (E)-nerolidol
567 2175-2183 Chemical denotes hydrogen MESH:D006859
568 2199-2206 Chemical denotes alcohol MESH:D000438
569 2217-2223 Chemical denotes Gln192
570 2228-2234 Chemical denotes Thr190
571 2255-2268 Chemical denotes (E)-nerolidol
572 2280-2286 Chemical denotes GLN189
573 2291-2297 Chemical denotes ARG188
602 2347-2357 Species denotes SARS-CoV-2 Tax:2697049
603 2463-2471 Species denotes SARS-CoV Tax:694009
604 2564-2572 Species denotes SARS-CoV Tax:694009
605 2593-2597 Species denotes E)-α Tax:114629
606 2634-2649 Chemical denotes (E)-β-farnesene
607 2676-2690 Chemical denotes (E,E)-farnesol
608 2721-2734 Chemical denotes (E)-nerolidol
609 2774-2790 Chemical denotes sesquiterpenoids MESH:D012717
610 2863-2869 Chemical denotes Gln347
611 2871-2877 Chemical denotes Ile328
612 2879-2885 Chemical denotes Val276
613 2887-2893 Chemical denotes Ser274
614 2895-2901 Chemical denotes Thr275
615 2903-2909 Chemical denotes Ser329
616 2911-2916 Chemical denotes Asn74
617 2918-2923 Chemical denotes Asn75
618 2925-2931 Chemical denotes Glu327
619 2937-2942 Chemical denotes Lys71
620 2998-3012 Chemical denotes (E,E)-farnesol
621 3020-3028 Chemical denotes hydrogen MESH:D006859
622 3055-3061 Chemical denotes Ser329
623 3066-3072 Chemical denotes Glu327
624 3080-3093 Chemical denotes (E)-nerolidol
625 3094-3102 Chemical denotes hydrogen MESH:D006859
626 3115-3120 Chemical denotes Asn75
627 3125-3130 Chemical denotes Lys71
628 3230-3243 Chemical denotes essential oil MESH:D009822
629 2512-2527 Disease denotes viral infection MESH:D001102
651 3534-3544 Species denotes SARS-CoV-2 Tax:2697049
652 3628-3638 Species denotes SARS-CoV-2 Tax:2697049
653 3693-3703 Species denotes SARS-CoV-2 Tax:2697049
654 3916-3926 Species denotes SARS-CoV-2 Tax:2697049
655 4016-4020 Species denotes E)-α Tax:114629
656 3388-3415 Chemical denotes ADP-ribose 1″-monophosphate
657 3417-3426 Chemical denotes Appr-1″-p
658 3431-3441 Chemical denotes ADP-ribose MESH:D000246
659 3575-3589 Chemical denotes (E,E)-farnesol
660 3726-3732 Chemical denotes Phe132
661 3734-3739 Chemical denotes Asn40
662 3741-3747 Chemical denotes Ile131
663 3749-3754 Chemical denotes Ala38
664 3760-3765 Chemical denotes Ala39
665 3772-3780 Chemical denotes hydrogen MESH:D006859
666 3820-3827 Chemical denotes alcohol MESH:D000438
667 3832-3837 Chemical denotes Asn40
668 4319-4339 Chemical denotes β-sesquiphellandrene
669 4344-4357 Chemical denotes α-zingiberene
670 4453-4459 Chemical denotes phytol MESH:D010836
671 4464-4471 Chemical denotes phytone
675 4824-4828 Gene denotes RdRp Gene:43740578
676 4813-4823 Species denotes SARS-CoV-2 Tax:2697049
677 4932-4946 Chemical denotes (E,E)-farnesol
710 4991-4996 Gene denotes spike Gene:43740568
711 5025-5056 Gene denotes angiotensin-converting enzyme 2 Gene:59272
712 5058-5062 Gene denotes ACE2 Gene:59272
713 5143-5147 Gene denotes ACE2 Gene:59272
714 5221-5225 Gene denotes ACE2 Gene:59272
715 5273-5277 Gene denotes ACE2 Gene:59272
716 5581-5585 Gene denotes ACE2 Gene:59272
717 5757-5761 Gene denotes ACE2 Gene:59272
718 5829-5833 Gene denotes ACE2 Gene:59272
719 5902-5907 Gene denotes spike Gene:43740568
720 5926-5930 Gene denotes ACE2 Gene:59272
721 5563-5568 Gene denotes spike Gene:43740568
722 4980-4990 Species denotes SARS-CoV-2 Tax:2697049
723 5071-5076 Species denotes human Tax:9606
724 5119-5129 Species denotes SARS-CoV-2 Tax:2697049
725 5137-5142 Species denotes human Tax:9606
726 5198-5208 Species denotes SARS-CoV-2 Tax:2697049
727 5215-5220 Species denotes human Tax:9606
728 5267-5272 Species denotes human Tax:9606
729 5354-5358 Species denotes E)-α Tax:114629
730 5552-5562 Species denotes SARS-CoV-2 Tax:2697049
731 5891-5901 Species denotes SARS-CoV-2 Tax:2697049
732 5920-5925 Species denotes human Tax:9606
733 5645-5651 Chemical denotes Pro565
734 5653-5658 Chemical denotes Leu95
735 5660-5666 Chemical denotes Val209
736 5668-5674 Chemical denotes Asn210
737 5676-5681 Chemical denotes Leu91
738 5683-5688 Chemical denotes Lys94
739 5690-5696 Chemical denotes Glu208
740 5702-5708 Chemical denotes Glu564
741 5799-5812 Chemical denotes essential oil MESH:D009822
764 6196-6201 Gene denotes spike Gene:43740568
765 6257-6262 Gene denotes spike Gene:43740568
766 6281-6285 Gene denotes ACE2 Gene:59272
767 6544-6548 Gene denotes ACE2 Gene:59272
768 6084-6088 Species denotes E)-α Tax:114629
769 6185-6195 Species denotes SARS-CoV-2 Tax:2697049
770 6246-6256 Species denotes SARS-CoV-2 Tax:2697049
771 6275-6280 Species denotes human Tax:9606
772 6520-6530 Species denotes SARS-CoV-2 Tax:2697049
773 6538-6543 Species denotes human Tax:9606
774 5978-5991 Chemical denotes essential oil MESH:D009822
775 6047-6067 Chemical denotes (E)-cinnamyl acetate MESH:C526329
776 6069-6079 Chemical denotes eremanthin MESH:C002601
777 6100-6115 Chemical denotes (E)-β-farnesene
778 6117-6131 Chemical denotes (E,E)-farnesol
779 6137-6152 Chemical denotes geranyl formate MESH:C572439
780 6350-6356 Chemical denotes Tyr505
781 6358-6364 Chemical denotes Tyr495
782 6366-6372 Chemical denotes Asn501
783 6374-6380 Chemical denotes Arg403
784 6382-6388 Chemical denotes Tyr453
785 6394-6400 Chemical denotes Gly502
789 6836-6854 Species denotes Bacillus anthracis Tax:1392
790 6921-6936 Species denotes Russell’s viper Tax:8707
791 6592-6605 Chemical denotes essential oil MESH:D009822
800 7237-7247 Species denotes SARS-CoV-2 Tax:2697049
801 7266-7270 Species denotes E)-α Tax:114629
802 7677-7687 Species denotes SARS-CoV-2 Tax:2697049
803 7135-7148 Chemical denotes essential oil MESH:D009822
804 7282-7297 Chemical denotes (E)-β-farnesene
805 7303-7317 Chemical denotes (E,E)-farnesol
806 7381-7395 Chemical denotes sesquiterpenes MESH:D012717
807 7568-7581 Chemical denotes essential oil MESH:D009822
821 7784-7794 Species denotes SARS-CoV-2 Tax:2697049
822 7913-7923 Species denotes SARS-CoV-2 Tax:2697049
823 8158-8163 Species denotes HSV-1 Tax:10298
824 8246-8254 Species denotes tea tree Tax:164405
825 8168-8178 Species denotes Eucalyptus Tax:34317
826 7731-7744 Chemical denotes essential oil MESH:D009822
827 7811-7824 Chemical denotes essential oil MESH:D009822
828 7950-7964 Chemical denotes essential oils MESH:D009822
829 8011-8024 Chemical denotes essential oil MESH:D009822
830 8224-8235 Chemical denotes 1,8-cineole MESH:D000077591
831 8312-8325 Chemical denotes terpinen-4-ol MESH:C034019
832 8327-8338 Chemical denotes γ-terpinene MESH:C018669
833 8344-8355 Chemical denotes α-terpinene MESH:C018669
843 8526-8543 Species denotes Mentha suaveolens Tax:38860
844 8575-8580 Species denotes HSV-1 Tax:10298
845 8597-8616 Species denotes Melissa officinalis Tax:39338
846 8679-8700 Species denotes avian influenza virus Tax:11309
847 8701-8705 Species denotes H9N2 Tax:102796
848 8414-8428 Chemical denotes essential oils MESH:D009822
849 8562-8571 Chemical denotes acyclovir MESH:D000212
850 8659-8670 Chemical denotes oseltamivir MESH:D053139
851 8726-8740 Chemical denotes essential oils MESH:D009822
859 8916-8930 Chemical denotes essential oils MESH:D009822
860 8945-8953 Chemical denotes linalool MESH:C018584
861 8996-9007 Chemical denotes 1,8-cineole MESH:D000077591
862 9076-9083 Chemical denotes menthol MESH:D008610
863 9095-9102 Chemical denotes camphor MESH:D002164
864 9118-9124 Chemical denotes thymol MESH:D013943
865 8895-8903 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T73 68-115 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T74 68-101 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T75 117-125 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T76 204-228 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T77 230-238 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T78 271-279 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 297-305 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T80 315-323 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T81 345-353 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T82 371-379 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T83 409-417 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T84 427-435 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T85 468-476 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 512-520 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T87 538-546 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T88 778-786 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T89 996-1004 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T90 1077-1085 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T91 1130-1138 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 1183-1191 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T93 1282-1290 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T94 1620-1628 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T95 1776-1784 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T96 2347-2355 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T97 2463-2471 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T98 2512-2527 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T99 2518-2527 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T100 2564-2572 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T101 3534-3542 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 3628-3636 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T103 3693-3701 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T104 3916-3924 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T105 4813-4821 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T106 4980-4988 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T107 5119-5127 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T108 5198-5206 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T109 5552-5560 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T110 5891-5899 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T111 6185-6193 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T112 6246-6254 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T113 6520-6528 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T114 7237-7245 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T115 7677-7685 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T116 7784-7792 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T117 7913-7921 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T118 8679-8694 Disease denotes avian influenza http://purl.obolibrary.org/obo/MONDO_0018695
T119 8685-8694 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T120 8895-8903 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T106 549-551 http://purl.obolibrary.org/obo/CLO_0008882 denotes rS
T107 558-563 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T108 915-916 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T109 1141-1143 http://purl.obolibrary.org/obo/CLO_0008882 denotes rS
T110 1302-1303 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T111 1468-1469 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T112 1532-1538 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T113 2443-2446 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T114 2818-2819 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T115 2843-2862 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T116 2843-2862 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T117 3309-3310 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T118 3475-3480 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T119 4640-4647 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T120 5071-5081 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cell
T121 5130-5132 http://purl.obolibrary.org/obo/CLO_0008882 denotes rS
T122 5137-5142 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T123 5157-5158 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T124 5209-5211 http://purl.obolibrary.org/obo/CLO_0008882 denotes rS
T125 5215-5220 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T126 5267-5272 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T127 5492-5493 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T128 5494-5500 http://purl.obolibrary.org/obo/UBERON_0002553 denotes cavity
T129 5603-5609 http://purl.obolibrary.org/obo/UBERON_0002553 denotes cavity
T130 5613-5614 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 5920-5925 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T132 6275-6280 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T133 6319-6320 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T134 6531-6533 http://purl.obolibrary.org/obo/CLO_0008882 denotes rS
T135 6538-6543 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T136 6698-6703 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T137 6951-6953 http://purl.obolibrary.org/obo/CLO_0001562 denotes A2
T138 8075-8080 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T139 8148-8156 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T140 8259-8262 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T141 8263-8264 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T142 8283-8291 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T143 8357-8359 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T144 8647-8655 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T145 8695-8700 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T146 8807-8816 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T147 8818-8821 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T148 8845-8853 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T149 9066-9074 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T150 9148-9158 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T158 34-42 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T159 247-254 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T160 382-385 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T163 386-392 Chemical denotes ribose http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013
T165 529-536 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T166 564-575 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T167 850-855 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T168 966-990 Chemical denotes essential oil components http://purl.obolibrary.org/obo/CHEBI_27311
T169 966-979 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T170 1304-1312 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T171 1644-1657 Chemical denotes sesquiterpene http://purl.obolibrary.org/obo/CHEBI_35189
T172 1658-1669 Chemical denotes hydrocarbon http://purl.obolibrary.org/obo/CHEBI_24632
T173 1676-1685 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T174 1718-1742 Chemical denotes essential oil components http://purl.obolibrary.org/obo/CHEBI_27311
T175 1718-1731 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T176 1805-1814 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T177 1841-1855 Chemical denotes (E,E)-farnesol http://purl.obolibrary.org/obo/CHEBI_16619
T178 1847-1855 Chemical denotes farnesol http://purl.obolibrary.org/obo/CHEBI_28600
T179 1890-1899 Chemical denotes nerolidol http://purl.obolibrary.org/obo/CHEBI_7524
T180 1930-1943 Chemical denotes sesquiterpene http://purl.obolibrary.org/obo/CHEBI_35189
T181 1944-1956 Chemical denotes hydrocarbons http://purl.obolibrary.org/obo/CHEBI_24632
T182 1965-1974 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T183 1985-1994 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T184 2076-2079 Chemical denotes Asp http://purl.obolibrary.org/obo/CHEBI_17053|http://purl.obolibrary.org/obo/CHEBI_22660|http://purl.obolibrary.org/obo/CHEBI_29958
T187 2135-2149 Chemical denotes (E,E)-farnesol http://purl.obolibrary.org/obo/CHEBI_16619
T188 2141-2149 Chemical denotes farnesol http://purl.obolibrary.org/obo/CHEBI_28600
T189 2158-2167 Chemical denotes nerolidol http://purl.obolibrary.org/obo/CHEBI_7524
T190 2175-2183 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T191 2199-2206 Chemical denotes alcohol http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T193 2259-2268 Chemical denotes nerolidol http://purl.obolibrary.org/obo/CHEBI_7524
T194 2325-2332 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T195 2416-2425 Chemical denotes uridylate http://purl.obolibrary.org/obo/CHEBI_16695
T196 2552-2559 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T197 2598-2607 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T198 2640-2649 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T199 2676-2690 Chemical denotes (E,E)-farnesol http://purl.obolibrary.org/obo/CHEBI_16619
T200 2682-2690 Chemical denotes farnesol http://purl.obolibrary.org/obo/CHEBI_28600
T201 2725-2734 Chemical denotes nerolidol http://purl.obolibrary.org/obo/CHEBI_7524
T202 2774-2790 Chemical denotes sesquiterpenoids http://purl.obolibrary.org/obo/CHEBI_26658
T203 2843-2853 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T204 2843-2848 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T205 2849-2853 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T206 2998-3012 Chemical denotes (E,E)-farnesol http://purl.obolibrary.org/obo/CHEBI_16619
T207 3004-3012 Chemical denotes farnesol http://purl.obolibrary.org/obo/CHEBI_28600
T208 3020-3028 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T209 3084-3093 Chemical denotes nerolidol http://purl.obolibrary.org/obo/CHEBI_7524
T210 3094-3102 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T211 3187-3194 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T212 3230-3254 Chemical denotes essential oil components http://purl.obolibrary.org/obo/CHEBI_27311
T213 3230-3243 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T214 3265-3272 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T215 3340-3350 Chemical denotes ADP ribose http://purl.obolibrary.org/obo/CHEBI_16960
T216 3340-3343 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T219 3344-3350 Chemical denotes ribose http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013
T221 3388-3391 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T224 3392-3398 Chemical denotes ribose http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013
T226 3431-3434 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T229 3435-3441 Chemical denotes ribose http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013
T231 3575-3589 Chemical denotes (E,E)-farnesol http://purl.obolibrary.org/obo/CHEBI_16619
T232 3581-3589 Chemical denotes farnesol http://purl.obolibrary.org/obo/CHEBI_28600
T233 3772-3780 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T234 3813-3819 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T235 3820-3827 Chemical denotes alcohol http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T237 3861-3885 Chemical denotes essential oil components http://purl.obolibrary.org/obo/CHEBI_27311
T238 3861-3874 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T239 3944-3957 Chemical denotes sesquiterpene http://purl.obolibrary.org/obo/CHEBI_35189
T240 3958-3970 Chemical denotes hydrocarbons http://purl.obolibrary.org/obo/CHEBI_24632
T241 3977-3986 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T242 4021-4030 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T243 4110-4121 Chemical denotes zingiberene http://purl.obolibrary.org/obo/CHEBI_10115
T244 4152-4164 Chemical denotes diterpenoids http://purl.obolibrary.org/obo/CHEBI_23849
T245 4165-4171 Chemical denotes phytol http://purl.obolibrary.org/obo/CHEBI_17327
T246 4243-4258 Chemical denotes phenylpropanoid http://purl.obolibrary.org/obo/CHEBI_26004
T247 4267-4274 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622
T249 4346-4357 Chemical denotes zingiberene http://purl.obolibrary.org/obo/CHEBI_10115
T250 4453-4459 Chemical denotes phytol http://purl.obolibrary.org/obo/CHEBI_17327
T251 4525-4527 Chemical denotes 5B http://purl.obolibrary.org/obo/CHEBI_27560
T252 4732-4741 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T253 4783-4807 Chemical denotes essential oil components http://purl.obolibrary.org/obo/CHEBI_27311
T254 4783-4796 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T255 4893-4899 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T256 4932-4946 Chemical denotes (E,E)-farnesol http://purl.obolibrary.org/obo/CHEBI_16619
T257 4938-4946 Chemical denotes farnesol http://purl.obolibrary.org/obo/CHEBI_28600
T258 4997-5004 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T259 5025-5036 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T260 5254-5261 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T261 5359-5368 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T262 5376-5385 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T263 5387-5401 Chemical denotes (E,E)-farnesol http://purl.obolibrary.org/obo/CHEBI_16619
T264 5393-5401 Chemical denotes farnesol http://purl.obolibrary.org/obo/CHEBI_28600
T265 5407-5416 Chemical denotes nerolidol http://purl.obolibrary.org/obo/CHEBI_7524
T266 5569-5576 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T267 5799-5823 Chemical denotes essential oil components http://purl.obolibrary.org/obo/CHEBI_27311
T268 5799-5812 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T269 5851-5858 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T270 5859-5866 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T271 5908-5915 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T272 5978-6002 Chemical denotes essential oil components http://purl.obolibrary.org/obo/CHEBI_27311
T273 5978-5991 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T274 6051-6067 Chemical denotes cinnamyl acetate http://purl.obolibrary.org/obo/CHEBI_31402
T275 6060-6067 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622
T277 6089-6098 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T278 6106-6115 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T279 6117-6131 Chemical denotes (E,E)-farnesol http://purl.obolibrary.org/obo/CHEBI_16619
T280 6123-6131 Chemical denotes farnesol http://purl.obolibrary.org/obo/CHEBI_28600
T281 6145-6152 Chemical denotes formate http://purl.obolibrary.org/obo/CHEBI_15740|http://purl.obolibrary.org/obo/CHEBI_52343
T283 6202-6209 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T284 6263-6270 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T285 6592-6616 Chemical denotes essential oil components http://purl.obolibrary.org/obo/CHEBI_27311
T286 6592-6605 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T287 6628-6636 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T288 6704-6712 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T289 6737-6744 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T290 6855-6865 Chemical denotes nicotinate http://purl.obolibrary.org/obo/CHEBI_32544
T291 6866-6880 Chemical denotes mononucleotide http://purl.obolibrary.org/obo/CHEBI_29075
T292 6998-7007 Chemical denotes aspartate http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314
T295 7072-7080 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T296 7135-7159 Chemical denotes essential oil components http://purl.obolibrary.org/obo/CHEBI_27311
T297 7135-7148 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T298 7191-7199 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T299 7226-7233 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T300 7271-7280 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T301 7288-7297 Chemical denotes farnesene http://purl.obolibrary.org/obo/CHEBI_39237
T302 7303-7317 Chemical denotes (E,E)-farnesol http://purl.obolibrary.org/obo/CHEBI_16619
T303 7309-7317 Chemical denotes farnesol http://purl.obolibrary.org/obo/CHEBI_28600
T304 7359-7367 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T305 7381-7395 Chemical denotes sesquiterpenes http://purl.obolibrary.org/obo/CHEBI_35189
T306 7568-7581 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T307 7582-7589 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T308 7652-7660 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T309 7688-7696 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T310 7731-7755 Chemical denotes essential oil components http://purl.obolibrary.org/obo/CHEBI_27311
T311 7731-7744 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T312 7765-7772 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T313 7811-7835 Chemical denotes essential oil components http://purl.obolibrary.org/obo/CHEBI_27311
T314 7811-7824 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T315 7931-7939 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T316 7950-7964 Chemical denotes essential oils http://purl.obolibrary.org/obo/CHEBI_83630
T317 8011-8035 Chemical denotes essential oil components http://purl.obolibrary.org/obo/CHEBI_27311
T318 8011-8024 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T319 8138-8147 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T320 8224-8235 Chemical denotes 1,8-cineole http://purl.obolibrary.org/obo/CHEBI_27961
T321 8228-8235 Chemical denotes cineole http://purl.obolibrary.org/obo/CHEBI_23243
T322 8246-8258 Chemical denotes tea tree oil http://purl.obolibrary.org/obo/CHEBI_83629
T323 8273-8282 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T324 8414-8428 Chemical denotes essential oils http://purl.obolibrary.org/obo/CHEBI_83630
T325 8443-8459 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T326 8498-8507 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T327 8544-8557 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T328 8562-8571 Chemical denotes acyclovir http://purl.obolibrary.org/obo/CHEBI_2453
T329 8617-8630 Chemical denotes essential oil http://purl.obolibrary.org/obo/CHEBI_83630
T330 8659-8670 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T331 8726-8740 Chemical denotes essential oils http://purl.obolibrary.org/obo/CHEBI_83630
T332 8835-8844 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T333 8916-8930 Chemical denotes essential oils http://purl.obolibrary.org/obo/CHEBI_83630
T334 8945-8953 Chemical denotes linalool http://purl.obolibrary.org/obo/CHEBI_17580
T335 8967-8980 Chemical denotes caryophyllene http://purl.obolibrary.org/obo/CHEBI_10357
T336 8996-9007 Chemical denotes 1,8-cineole http://purl.obolibrary.org/obo/CHEBI_27961
T337 9000-9007 Chemical denotes cineole http://purl.obolibrary.org/obo/CHEBI_23243
T338 9095-9102 Chemical denotes camphor http://purl.obolibrary.org/obo/CHEBI_36773
T339 9118-9124 Chemical denotes thymol http://purl.obolibrary.org/obo/CHEBI_27607
T340 9136-9147 Chemical denotes antitussive http://purl.obolibrary.org/obo/CHEBI_51177

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T6 1835-1843 Phenotype denotes mol), (E http://purl.obolibrary.org/obo/HP_0003764
T7 2628-2636 Phenotype denotes mol), (E http://purl.obolibrary.org/obo/HP_0003764
T8 2670-2678 Phenotype denotes mol), (E http://purl.obolibrary.org/obo/HP_0003764
T9 4007-4015 Phenotype denotes mol), (E http://purl.obolibrary.org/obo/HP_0003764
T10 6042-6050 Phenotype denotes mol; (E) http://purl.obolibrary.org/obo/HP_0003764

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T7 247-262 http://purl.obolibrary.org/obo/GO_0006605 denotes protein targets
T8 396-407 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T9 2512-2527 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T10 3351-3362 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T11 4569-4584 http://purl.obolibrary.org/obo/GO_0039703 denotes RNA replication
T12 4686-4703 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T13 4686-4703 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T14 7765-7780 http://purl.obolibrary.org/obo/GO_0006605 denotes protein targets

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T74 0-2 Sentence denotes 2.
T75 3-25 Sentence denotes Results and Discussion
T76 26-240 Sentence denotes Several proteins have been identified for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may serve as potential targets for chemotherapeutic intervention in coronavirus disease 2019 (COVID-19).
T77 241-602 Sentence denotes These protein targets include SARS-CoV-2 main protease (SARS-CoV-2 Mpro), SARS-CoV-2 endoribonucleoase (SARS-CoV-2 Nsp15/NendoU), SARS-CoV-2 ADP−ribose−1″−phosphatase (SARS-CoV-2 ADRP), SARS-CoV-2 RNA-dependent RNA polymerase (SARS-CoV-2 RdRp), the binding domain of the SARS-CoV-2 spike protein (SARS-CoV-2 rS), and human angiotensin−converting enzyme (hACE2).
T78 603-693 Sentence denotes There have already been several molecular docking studies on these macromolecular targets.
T79 694-812 Sentence denotes Several groups have carried out molecular docking of natural product libraries with SARS-CoV-2 Mpro [102,103,104,105].
T80 813-914 Sentence denotes Additionally, commercially available drugs have also been examined using in silico methods [106,107].
T81 915-1017 Sentence denotes A molecular docking study was carried out with 171 essential oil components with SARS-CoV-2 Mpro (PDB:
T82 1018-1106 Sentence denotes 5R7Z, 5R80, 5R81, 5R82, 5R83, 5R84, 6LU7, 6M03, and 6Y84), SARS-CoV-2 Nsp15/NendoU (PDB:
T83 1107-1149 Sentence denotes 6VWW, 6W01, and 6W02), SARS-CoV-2 rS (PDB:
T84 1150-1204 Sentence denotes 6M0J, 6M17, 6VX1, and 6VW1), and SARS-CoV-2 RdRp (PDB:
T85 1205-1211 Sentence denotes 6M71).
T86 1212-1262 Sentence denotes The best docking scores are summarized in Table 3.
T87 1263-1423 Sentence denotes The main protease, SARS-CoV-2 Mpro, is a cysteine protease that is essential for processing the polyproteins that are translated from the coronavirus RNA [108].
T88 1424-1564 Sentence denotes The substrate binding site of the enzyme is a cleft flanked by Gln189, Met49, Pro168, Glu166 and His41; the active site is Cys145 and His41.
T89 1565-1711 Sentence denotes The compound with the best normalized docking score to SARS-CoV-2 Mpro was the sesquiterpene hydrocarbon (E)-β-farnesene (DSnorm = −115.4 kJ/mol).
T90 1712-1925 Sentence denotes Other essential oil components showing good docking scores with SARS-CoV-2 Mpro were (E,E)-α-farnesene (DSnorm = −115.0 kJ/mol), (E,E)-farnesol (DSnorm = −112.4 kJ/mol), and (E)-nerolidol (DSnorm = −110.7 kJ/mol).
T91 1926-2095 Sentence denotes The sesquiterpene hydrocarbons (E,E)-α-farnesene and (E)-β-farnesene occupy the substrate binding site, flanked by Gln189, Arg188, Met165, His41, and Asp 187 (Figure 1).
T92 2096-2309 Sentence denotes The lowest-energy docked poses of both (E,E)-farnesol and (E)-nerolidol showed hydrogen bonding of the alcohol moiety to Gln192 and Thr190 and, in the case of (E)-nerolidol, also with GLN189 and ARG188 (Figure 2).
T93 2310-2426 Sentence denotes Non-structural protein 15 (Nsp15) of SARS-CoV-2 is an endoribonuclease that preferentially cleaves RNA at uridylate.
T94 2427-2534 Sentence denotes Furthermore, it has been shown that SARS-CoV Nsp15/NendoU is required for successful viral infection [109].
T95 2535-2760 Sentence denotes The best docking ligands for SARS-CoV Nsp15/NendoU are (E,E)-α-farnesene (DSnorm = −107.5 kJ/mol), (E)-β-farnesene (DSnorm = −105.0 kJ/mol), (E,E)-farnesol (DSnorm = −104.6 kJ/mol), and (E)-nerolidol (DSnorm = −101.6 kJ/mol).
T96 2761-2954 Sentence denotes All of these sesquiterpenoids preferentially docked into a binding site formed by amino acid residues Gln347, Ile328, Val276, Ser274, Thr275, Ser329, Asn74, Asn75, Glu327, and Lys71 (Figure 3).
T97 2955-3142 Sentence denotes In addition to van der Waals interactions, (E,E)-farnesol showed hydrogen-bonding interactions with Ser329 and Glu327, while (E)-nerolidol hydrogen bonded with Asn75 and Lys71 (Figure 3).
T98 3143-3339 Sentence denotes Unfortunately, the docking scores for these ligands as well as the scores of the other essential oil components with this protein are too low for it to be considered a viable target (see Table 3).
T99 3340-3499 Sentence denotes ADP ribose phosphatase (ADRP) serves to convert ADP-ribose 1″-monophosphate (Appr-1″-p) to ADP-ribose (Appr), which serves to regulate virus replication [110].
T100 3500-3560 Sentence denotes This enzyme may be dispensable in SARS-CoV-2, however [111].
T101 3561-3672 Sentence denotes Nevertheless, (E,E)-farnesol showed the most exothermic docking to SARS-CoV-2 ADRP with DSnorm = −121.4 kJ/mol.
T102 3673-3849 Sentence denotes The binding site in SARS-CoV-2 ADRP is surrounded by Phe132, Asn40, Ile131, Ala38, and Ala39, with hydrogen-bonded interactions between the ligand alcohol and Asn40 (Figure 4).
T103 3850-4300 Sentence denotes Additional essential oil components with good docking scores with SARS-CoV-2 ADRP include the sesquiterpene hydrocarbons (E)-β-farnesene (DSnorm = −116.3 kJ/mol), (E,E)-α-farnesene (DSnorm = −114.2 kJ/mol), β-sesquiphellandrene (DSnorm = −115.7 kJ/mol), and α-zingiberene (DSnorm = −115.4 kJ/mol); the diterpenoids phytol (DSnorm = −118.9 kJ/mol) and phytone (DSnorm = −116.9 kJ/mol); and the phenylpropanoid eugenyl acetate (DSnorm = −115.4 kJ/mol).
T104 4301-4441 Sentence denotes Not surprisingly, β-sesquiphellandrene and α-zingiberene adopted the same docking orientation in the binding site of the enzyme (Figure 5A).
T105 4442-4529 Sentence denotes Similarly, phytol and phytone occupy the same location in the binding site (Figure 5B).
T106 4530-4648 Sentence denotes RNA-dependent RNA polymerase catalyzes RNA replication from an RNA template and is an essential enzyme in RNA viruses.
T107 4649-4761 Sentence denotes Because these enzymes are crucial in viral replication, they are viable targets in antiviral chemotherapy [112].
T108 4762-4888 Sentence denotes Molecular docking of essential oil components with SARS-CoV-2 RdRp showed only weak docking with this enzyme target (Table 3).
T109 4889-4975 Sentence denotes The ligand with the best docking score was (E,E)-farnesol, with DSnorm = −89.6 kJ/mol.
T110 4976-5096 Sentence denotes The SARS-CoV-2 spike protein serves to attach to angiotensin-converting enzyme 2 (ACE2) of the human cell to be invaded.
T111 5097-5236 Sentence denotes The interface between SARS-CoV-2 rS and human ACE2 would be a promising target to prevent binding of SARS-CoV-2 rS to human ACE2 [113,114].
T112 5237-5597 Sentence denotes The best docking ligands with human ACE2, i.e., normalized docking scores < -100 kJ/mol (α-bulnesene, eremanthin, (E,E)-α-farnesene, (E)-β-farnesene, (E,E)-farnesol, (E)-nerolidol, β-sesquiphellandrene, and (Z)-spiroether), all show docking preference to a cavity removed from the interaction interface between the SARS-CoV-2 spike protein and ACE2 (Figure 6).
T113 5598-5709 Sentence denotes This cavity is a pocket surrounded by residues Pro565, Leu95, Val209, Asn210, Leu91, Lys94, Glu208, and Glu564.
T114 5710-5931 Sentence denotes Because of the remote location of docking with ACE2, it is predicted that interaction of essential oil components with ACE2 will not prevent protein–protein interaction between the SARS-CoV-2 spike protein and human ACE2.
T115 5932-6297 Sentence denotes On the other hand, the lowest energy poses of essential oil components showing the strongest docking (<−80 kJ/mol; (E)-cinnamyl acetate, eremanthin, (E,E)-α-farnesene, (E)-β-farnesene, (E,E)-farnesol, and geranyl formate) with the binding domain of the SARS-CoV-2 spike protein do lie at the interface between the SARS-CoV-2 spike protein and human ACE2 (Figure 6).
T116 6298-6401 Sentence denotes This docking site is a hydrophobic pocket formed by Tyr505, Tyr495, Asn501, Arg403, Tyr453, and Gly502.
T117 6402-6549 Sentence denotes Unfortunately, the docking energies at this site are too weak and are unlikely, therefore, to disrupt binding between SARS-CoV-2 rS and human ACE2.
T118 6550-6713 Sentence denotes In order to compare docking scores of the essential oil components with other proteins, docking was also carried out with six randomly selected non-virus proteins:
T119 6714-6757 Sentence denotes Bovine odorant binding protein (BtOBP, PDB:
T120 6758-6778 Sentence denotes 1GT3), cruzain (PDB:
T121 6779-6828 Sentence denotes 1ME3), torpedo acetylcholinesterase (TcAChE, PDB:
T122 6829-6913 Sentence denotes 6G1U), Bacillus anthracis nicotinate mononucleotide adenylytransferase (BaNadD, PDB:
T123 6914-6967 Sentence denotes 3HFJ), Russell’s viper phospholipase A2 (DrPLA2, PDB:
T124 6968-7039 Sentence denotes 1FV0), and Escherichia coli l-aspartate aminotransferase (EcAspTA, PDB:
T125 7040-7046 Sentence denotes 2Q7W).
T126 7047-7107 Sentence denotes Docking scores for these proteins are summarized in Table 4.
T127 7108-7368 Sentence denotes The docking results of the essential oil components with the six randomly selected proteins indicate the best docking ligands to SARS-CoV-2 targets (i.e., (E,E)-α-farnesene, (E)-β-farnesene, and (E,E)-farnesol) have better docking energies with other proteins.
T128 7369-7547 Sentence denotes These three sesquiterpenes have docking energies of −129.8, −122.7, and −133.0 kJ/mol with TcAChE, respectively, and −131.8, −131.8, and −135.6 kJ/mol, respectively, with BaNadD.
T129 7548-7697 Sentence denotes Indeed, most of the essential oil ligands have better docking properties with one or more of the random proteins compared to the SARS-CoV-2 proteins.
T130 7698-7940 Sentence denotes Based on the docking energies of essential oil components with key protein targets of SARS-CoV-2, the individual essential oil components cannot be considered viable chemotherapeutic agents for interaction with the SARS-CoV-2 target proteins.
T131 7941-8081 Sentence denotes However, essential oils are complex mixtures of compounds and several essential oil components may act synergistically to inhibit the virus.
T132 8082-8361 Sentence denotes Astani and co-workers have shown, for example, that the antiviral activity (HSV-1) of Eucalyptus oil is much greater than the major component 1,8-cineole, and that tea tree oil has a greater antiviral activity than its components terpinen-4-ol, γ-terpinene, and α-terpinene [52].
T133 8362-8460 Sentence denotes Synergistic effects have also been observed between essential oils and synthetic antiviral agents.
T134 8461-8586 Sentence denotes Civitelli and co-workers observed an antiviral synergism between Mentha suaveolens essential oil and acyclovir on HSV-1 [64].
T135 8587-8712 Sentence denotes Likewise, Melissa officinalis essential oil potentiated the activity of oseltamivir against avian influenza virus H9N2 [115].
T136 8713-8823 Sentence denotes Furthermore, essential oils are lipophilic and therefore may also serve to disintegrate viral membranes [116].
T137 8824-8931 Sentence denotes Outside of antiviral activity, there may be some relief of symptoms of COVID-19 provided by essential oils.
T138 8932-9159 Sentence denotes For example, linalool [117,118], β-caryophyllene [119,120], and 1,8-cineole [121,122] have both anti-inflammatory and antinociceptive activity; menthol [123,124], camphor [125,126], and thymol [127] have antitussive activities.

2_test

Id Subject Object Predicate Lexical cue
32408699-32280433-52981861 905-908 32280433 denotes 106
32408699-16828802-52981862 2529-2532 16828802 denotes 109
32408699-16271890-52981863 3494-3497 16271890 denotes 110
32408699-16188975-52981864 3555-3558 16188975 denotes 111
32408699-17168760-52981865 4756-4759 17168760 denotes 112
32408699-32132184-52981866 5227-5230 32132184 denotes 113
32408699-32125455-52981867 5231-5234 32125455 denotes 114
32408699-24629600-52981868 8582-8584 24629600 denotes 64
32408699-27366768-52981869 8707-8710 27366768 denotes 115
32408699-10515903-52981870 8818-8821 10515903 denotes 116
32408699-12535857-52981871 8955-8958 12535857 denotes 117
32408699-26721216-52981872 8959-8962 26721216 denotes 118
32408699-24210682-52981873 8986-8989 24210682 denotes 120
32408699-23192000-52981874 9013-9016 23192000 denotes 122
32408699-7529306-52981875 9085-9088 7529306 denotes 123
32408699-24054028-52981876 9089-9092 24054028 denotes 124
32408699-7827436-52981877 9104-9107 7827436 denotes 125
32408699-23438788-52981878 9126-9129 23438788 denotes 127
T1060 905-908 32280433 denotes 106
T68467 2529-2532 16828802 denotes 109
T39189 3494-3497 16271890 denotes 110
T52591 3555-3558 16188975 denotes 111
T95080 4756-4759 17168760 denotes 112
T387 5227-5230 32132184 denotes 113
T49106 5231-5234 32125455 denotes 114
T47580 8582-8584 24629600 denotes 64
T80898 8707-8710 27366768 denotes 115
T63891 8818-8821 10515903 denotes 116
T47429 8955-8958 12535857 denotes 117
T69943 8959-8962 26721216 denotes 118
T24065 8986-8989 24210682 denotes 120
T8358 9013-9016 23192000 denotes 122
T29637 9085-9088 7529306 denotes 123
T83764 9089-9092 24054028 denotes 124
T95440 9104-9107 7827436 denotes 125
T81059 9126-9129 23438788 denotes 127