Conclusion We would like to highlight the importance of early admission and early treatment of CML patients with COVID-19, even if they present with mild symptoms or initially improved, and especially if they are on chemotherapy medications. Also, we emphasize the importance of the introduction of supportive management (oxygen with BiPAP, tocilizumab with pulse methylprednisolone) to control cytokine storm and other complications. Although ground-glass opacities are the typical radiological features of COVID-19, it could be presented with other radiological findings like unilateral or bilateral pleural effusion and might be complicated by ARDS as in our case.