mble endolysosomal compartments, and increases their pH to stop the nutrient supply [18]. Another interesting example of lysosomotropic pharmaceuticals are drugs used for the treatment of tuberculosis, where the drug has to reach both extracellular bacilli in the interstitial compartments and caseum, and intracellular pathogens residing in phagolysosomes of immune cells [18,19]. Consequently, retention of antituberculosis drugs in infected phagolysosomes has been considered an important factor