Stage 5 Sepsis Organ failure caused by deregulated host response to infection. Signs of organ failure include altered mental status, difficult or superficial respiration, increased respiratory rate, low O2 peripheral saturation, oliguria/anuria, tachycardia, cold extremities, hypotension, and cutaneous alterations, and laboratory findings including altered coagulation, thrombocytopenia, acidosis, hyperbilirubinemia, and increased lactates.