Clinical features of SARS-CoV-2 infection overcame trauma and orthopaedic surgeons’ medical education; therefore, the ward activity was managed by a heterogeneous medical team, formed by one internist and one orthopaedic surgeon; one infectious disease specialist briefed with the medical team every day, for two hours. In cases of severe respiratory impairment, an ICU specialist was on call and rapidly available. The medical team briefed with the nursing team every day, at 8 a.m., 2 p.m., and 8 p.m. All clinical documentation was locked in the medical office; the informed consent module, after being signed by the patient, was stored in a plastic closed bag. Patients who needed emergency surgical treatment, or with laboratory and radiological findings inconsistent with clinical course, were treated with high suspicion and isolated in a “gray zone,” waiting for a clear diagnosis and distribution in white or red zone.