In term of biochemical indicators, patients with organ dysfunction, (including ARDS, acute renal injury, heart injury, liver dysfunction, pneumothorax, etc.) are prone to exhibit abnormal results of blood biochemical examination [47]. Increased serum N-terminal proB-type natriuretic peptide (NT-proBNP), cardiac troponin-I (cTnI), myoglobin and creatinine were related factors of critical COVID-19 with heart damage [48], [49]. Cardiac injury defined by the increase of hs-cTnI and D-dimer on admission and patients with high BNP is associated with a higher risk of mortality [50], [51], [52]. LDH, AST/ALT ratio, TBIL could be identified as powerful predictive factors for early recognition of liver injury and were positively correlated with death risk of COVID-19 patients [53], [54], [55]. Albumin, serum urea nitrogen and creatine were risk factor s for assessing kidney damage and disease progression [55], [56]. Many patients have abnormal urine analysis on admission, including proteinuria or hematuria, which indicates that urine analysis can better reveal the potential kidney damage of COVID-19 patients to reflect and predict the severity of the disease [57], [58]. In short, the cardiac biomarkers, liver and kidney function examination for severe and critically ill patients can evaluate the degree of extrapulmonary damage caused by complications.