3.2.5.2  Lymphocyte subsets
The total number of B cells, T cells and NK cells significantly decreased in patients with COVID-19 (852.9 /uL), and more evident in the severe cases (1.37-fold; 743.6 vs 1020.1 /uL; P = 0.032) compared to the non-severe group [13]. Lower levels of CD4 T cells (2.10-fold; 561.81 vs 266.79 cell/μl; P < 0.01), CD8 T cells (2.00-fold; 349.01 vs 174.61cell/μl; P < 0.01) were summarized in severe patients comparing with non-severe patients from 5 articles [14], [15], [16], [17], [18]. In addition, lower CD3 T cells (1.70-fold; 1070.23 vs 628.20 cell/μl; P < 0.01) in severe patients was noted in Liu et al. [18].