3.2.3.2  Liver function
The increase of alanine aminotransferase (ALT) (12.27% (296/2412)) and AST (14.87% (388/2609)) with COVID-19 has been observed. Moreover, the decrease of albumin (143/221 (64.70%)) was more common while the increase of total bilirubin (TBIL) was relatively rare in the majority of patients (109/1558 (6.70%)). Comparing with non-severe patients, higher ALT (1.34-fold; 33.78 vs 24.85 U/l; P < 0.01), AST (1.40-fold; 36.78 vs 26.24 U/l; P < 0.01), TBIL (1.14-fold; 11.86 vs 10.38 U/l; P = 0.024) and lower albumin (1.15-fold; 39.41vs 34.29 g/l; P < 0.01) of severe patients has been worked out.