Odler et al. [17] published the evaluation of 7 Fabry patients (40.2 ± 5.6 years) before and after ERT. At baseline, all patients had respiratory symptoms; however, these symptoms were usually mild. The most prominent lung function changes were registered in parameters reflecting small airway involvement, including significant decrease in FEF25 – 75, increase in residual volume (RV) and RV/ total lung capacity ratio. Furthermore, a review by Franzen et al. [18] found that obstructive lung disease was up to 10 times more frequent in patients with Fabry disease compared to the general population. The same author later reported the long-term follow-up of pulmonary function in 95 patients (41% males). The overall prevalence of bronchial obstruction was 46%, and FEV1 decreased 29 ml per year [19].