Rosenberg et al. [11] reported on light and electron microscopic evaluation of cells recovered from alveolar lavage fluid and from brushing the airway epithelium in 3 patients. In all of them, cytoplasmic inclusion bodies in ciliated epithelial cells and goblet cells were revealed. Sputum induced exam showed lamellar inclusion bodies within all ciliated bronchial epithelial cells examined in one patient. The same report examined sputum from five subjects without Fabry disease and were unable to find similar inclusions [14].