The pathogenesis and organ manifestations of SARS-CoV-2 virus are not fully understood [28]. Cytokine storm and viral evasion of cellular immune responses are considered to have crucial roles in the severity of COVID-19 [29]. In this study, patients with COVID-19 who had ocular manifestations had significantly high levels of CRP, PCT, and ESR, perhaps as a result of the active immune response of the host and disease severity. This may partly explain the positive association between high fever and ocular manifestations.