Coronaviruses  Receptor  Role in human CoV disease  Ocular surface (cell types)  Lung
SARS‐CoV
SARS‐CoV‐2  ACE2  Host cell receptor and essential for infection  + (conjunctival epithelium and fibroblasts; corneal epithelium) 31  + (airway epithelia)32, 33
TMPRSS2  Primes spike protein for binding to ACE2  –  + (airway epithelium) 34
CD209  Cell‐to‐cell viral transfer  + (corneal dendritic cells) 35  + (alveola macrophages) 36
MERS‐CoV  CD26  Host cell receptor and essential for infection  +/− (conjunctival vascular endothelium) 37  + (lung epithelia and endothelia) 38
CD66e  Co‐receptor  +/− (palpebral conjunctiva) 39  + (bronchial and alveolar epithelium) 32