Using animal models can help to determine whether the eye can become infected and the consequence of application of live virus to the eye. Unfortunately, most studies have not been designed specifically to examine the role of the eye in the disease process. Some studies have inoculated monkeys with SARSā€CoV intranasally and by topical application to the conjunctiva, and often also via their trachea.48, 49, 50 While the monkeys developed pneumonia, the role of the conjunctival inoculation cannot be analysed separately from the inoculation via the other routes.