To confirm and control this alarming incidence of COVID-19-associated IPA, a number of measures were taken. Firstly, we ruled out an environmental source, by sampling room air and the oxygen and pressurized air supplies (MAS 100, Merck). Prior to COVID-19, the incidence of IPA in our ICU was not elevated. Nonetheless, high-efficiency particulate air filters (HEPA) (Halton Vita, Helsinki, Finland) were installed in the ICU. Secondly, all mechanically ventilated COVID-19 patients were screened systematically by performing serum galactomannan assays twice weekly. Whenever a bronchoscopy was needed, BAL galactomannan indices and mould cultures were requested, regardless of the indication for bronchoscopy. Finally, we initiated prophylactic nebulization of 12.5 mg of liposomal amphotericin B (Ambisome®, Gilead, Foster City, USA) in every mechanically ventilated patient without an established diagnosis of IPA [8]. Since the implementation of these measures, we have not encountered any new cases of IPA at the time of writing.