Table 1 Patients with suspected IPA
Patient ID Sex (M/F) Age Medical history Time between COVID-19 symptoms and ICU admission (days) Time between COVID-19 symptoms and intubation (days) Time between intubation and first finding of IPA (days) First BAL galactomannan index Peak BAL galactomannan index First serum galactomannan index Peak serum galactomannan index
1 M 86 Hyperchol 7 7 9 N/A N/A 0.10 0.10
2 M 38 Obesity, hyperchol 9 9 6 2.40 > 2.80 0.30 0.30
3 M 62 DM 7 7 16 0.72 2.00 0.20 0.20
4 M 73 DM, obesity, AHT, hyperchol 9 10 5 2.65 > 2.80 0.10 0.10
5 M 77 DM, CKD, AHT, pemphigus foliaceus 9 10 2 2.79 2.79 0.10 0.10
6 M 55 HIV, AHT, hyperchol 8 9 13 0.69 0.69 0.18 0.80
7 M 75 AML, IPA (2012) 3 3 8 2.63 2.63 N/A N/A
Patient ID Sex (M/F) Age Medical history First positive culture CT scan Histological examinationa IPA diagnosis AspICU algorithm Antifungal therapy Outcome
1 M 86 Hyperchol A. flavus (ETA) No scan available N/A – – None Died, ICU day 10
2 M 38 Obesity, hyperchol A. fumigatus (BAL) + Positive Proven Absolute Voriconazole, isavuconazole Alive on MV, ICU day 28b
3 M 62 DM A. fumigatus (BAL) No scan available Positive Proven Absolute Voriconazole Died, ICU day 20
4 M 73 DM, obesity, AHT, hyperchol A. fumigatus (BAL) No scan available Positive Proven Absolute Voriconazole Alive on MV, ICU day 24b
5 M 77 DM, CKD, AHT, pemphigus foliaceus A. fumigatus (BAL) No scan available Positive Proven Absolute Voriconazole Alive on MV, ICU day 21b
6 M 55 HIV, AHT, hyperchol Negative No scan available Negative – Voriconazole, isavuconazole Died, ICU day 27
7 M 75 AML, IPA (2012) A. fumigatus (BAL) No scan available N/A – Voriconazole Died, ICU day 8
CKD chronic kidney disease, AML acute myeloid leukaemia, IPA invasive pulmonary aspergillosis. N/A no sample available, Hyperchol hypercholesterolaemia, AHT arterial hypertension, DM diabetes mellitus, BAL bronchoalveolar lavage, ETA endotracheal aspirate, MV mechanical ventilation arterial hypertension
aAnatomopathological examination of tissue samples obtained via bronchoscopy
bAt the time of writing