Currently, there are 17 clinical trials investigating the therapeutic potential of MSCs in COVID-19 patients that are registered on clinicaltrials.gov website; most of these trials are either recruiting patients or have not yet started the recruitment. The vast majority of the trials are selecting patients with COVID-19 and pneumonia, and utilizing allogeneic bone-marrow or umbilical cord-derived MSCs transplanted intravenously on three different occasions (Table 1). Approximately 50% of the trials are being carried out in China. Three trials (NCT03042143 already recruiting in Northern Ireland, United Kingdom; NCT04333368 planned in France and NCT04345601 in the United States of America, not yet recruiting) aim to investigate the therapeutic potential of MSCs in SARS-CoV-2-induced ARDS. MSCs have already been investigated in ARDS both in the pre-clinical (Curley et al., 2013) and clinical settings (Wilson et al., 2015), which demonstrated the ability of MSCs to promote distal lung epithelial repair, albeit potentially limited in the presence of hypercapnic acidosis (Fergie et al., 2019).