Results
Among the 2075 patients whose records were reviewed, 1256 were men, 819 were women, and the mean age was 67.57. At the time of collecting the data, 301 patients had died, 1447 had been discharged home from the hospitals, 201 were still admitted, and 126 had been transferred to hospitals not included in the study. Median follow up time was 8 (IQR 5–12) days. Among the 1734 patients who received heparin 242 had died. The patients treated with heparin were older than the ones who did not received it (p < 0.001) and the proportion of men and women who received heparin did not have significant difference (Table 1).
Table 1 Description of the patients included in the study
N Age M(SD) Female n(%) Death n(%)
Total cohort 2075 67.57 (15.52) 819 (39.47%) 301 (14.51%)
Oxygen saturation < 90% Yes 70 73.18 (13.7) 20 (28.57) 28 (53.85)
No 221 67.00 (16.14) 95 (42.99) 24 (46.15)
Temperature > 37° C Yes 159 61.20 (17.27) 47 (29.56) 24 (10.86)
No 1422 68.53 (15.65) 577 (40.58) 197 (89.14)
Heparin Yes 1734 68.77 (15.09) 686 (39.56) 242 (13.96)
No 285 61.76 (17.67) 96 (33.68) 44 (15.44)
Hydroxychloroquine Yes 1857 67.11 (15.51) 705 (37.96) 237 (12.76)
No 162 73.47 (16.22) 77 (47.53) 49 (30.25)
Azithromycin Yes 1223 68.33 (15.03) 456 (37.29) 146 (11.94)
No 796 66.54 (16.51) 326 (40.95) 140 (17.59)
Steroids Yes 960 69.88 (16.76) 330 (34.38) 200 (20.83)
No 1059 65.58 (16.76) 452 (42.68) 86 (8.12)
Tocilizumab Yes 421 66.1 (13.11) 117 (27.79) 89 (21.14)
No 1598 68.00 (16.24) 665 (41.61) 197 (12.33)
Lopinavir + Ritonavir Yes 1230 63.94 (14.28) 421 (34.23) 160 (13.01)
No 789 73.37 (15.99) 361 (45.75) 126 (15.97)
Oseltamivir Yes 132 67.78 (13.79) 51 (38.64) 26 (19.70)
No 1887 67.61 (15.78) 731 (38.74) 260 (13.78)
Heparin was associated with lower mortality when the model was adjusted for age and gender, with OR (95% CI) 0.55 (0.37–0.82) p = 0.003. This association remain significant when saturation of oxygen < 90%, and temperature > 37 °C were added to de model with OR 0.54 (0.36–0.82) p = 0.003, and also when all the other drugs were included as covariates OR 0.42 (0.26–0.66) p < 0.001.