Conclusion The COVID-19 pandemic has caused an unprecedented global impact on healthcare delivery, and its trajectory continues to remain unclear. Vulnerable patient populations include those with cardiovascular disease and cancer, and the cardio-oncology patient, having possessed both these risk factors, may unfortunately be at significantly increased risk of experiencing worse outcomes related to COVID-19 infection. As of this writing, there are no known studies focusing on the cardio-oncology population, and there remain many opportunities to not only study the epidemiology of this unique but also significant group of patients. Clinical trials are ongoing, but rigorous, randomized high-quality science is warranted to study the efficacy of previously mentioned treatments; they also may potentially reveal critical mechanistic insights into COVID-19’s pathophysiology, which overlap with cardiovascular and cancer disease states [114]. In addition, the abrupt and possibly permanent alteration of cardiovascular and cancer systems of care—with the dramatic rise of telemedicine and other changes—to mitigate transmission risk in the COVID-19 era also warrants close study to evaluate clinical outcomes. Much remains unknown about how the pandemic will affect the cardio-oncology population and how they will be cared for, but what is certain is that ongoing, close multidisciplinary care and communication between the cardiac and cancer care providers of these patients remains more critical than ever in order to guarantee the best care possible.