Although there are concerns regarding decreasing transmission risk by limiting healthcare interventions in COVID-19 disease, patients with severe infection who demonstrate either clinical signs of seizures or severe encephalopathy may benefit from continuous electroencephalography monitoring to diagnose and treat symptomatic seizures and also non-convulsive status epilepticus. The mechanism of seizures precipitated by SARS-CoV-2 infection appears to be multifactorial and may involve a possible neurotropism of SARS-CoV-2 in addition to blood–brain barrier breakdown precipitated by pro-inflammatory cytokine reactions.