PMC:7252096 / 18695-19235 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T64579","span":{"begin":17,"end":33},"obj":"Body_part"},{"id":"T18385","span":{"begin":28,"end":33},"obj":"Body_part"},{"id":"T26459","span":{"begin":133,"end":138},"obj":"Body_part"},{"id":"T74490","span":{"begin":165,"end":176},"obj":"Body_part"},{"id":"T57427","span":{"begin":194,"end":205},"obj":"Body_part"},{"id":"T45527","span":{"begin":311,"end":315},"obj":"Body_part"},{"id":"T71902","span":{"begin":395,"end":406},"obj":"Body_part"},{"id":"T62436","span":{"begin":518,"end":529},"obj":"Body_part"}],"attributes":[{"id":"A53774","pred":"fma_id","subj":"T64579","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A42956","pred":"fma_id","subj":"T18385","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A49853","pred":"fma_id","subj":"T26459","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A7631","pred":"fma_id","subj":"T74490","obj":"http://purl.org/sig/ont/fma/fma62499"},{"id":"A69042","pred":"fma_id","subj":"T57427","obj":"http://purl.org/sig/ont/fma/fma62499"},{"id":"A26271","pred":"fma_id","subj":"T45527","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A39144","pred":"fma_id","subj":"T71902","obj":"http://purl.org/sig/ont/fma/fma62499"},{"id":"A89061","pred":"fma_id","subj":"T62436","obj":"http://purl.org/sig/ont/fma/fma62499"}],"text":"ified subsets of epithelial cells expressing ACE2 and TMPRSS2 (Figure S1 ; Table S3; STAR Methods). The majority of ACE2 + TMPRSS2 + cells were, once again, type II pneumocytes (22%) and type I pneumocytes (9.7%) and were largely enriched within granulomatous regions compared with those in adjacent uninvolved lung (Figures S1B and S1C) (p = 0.006, Fisher Exact Test). ACE2 + TMPRSS2 + type II pneumocytes expressed significantly higher amounts of antimicrobial effectors such as LCN2 compared with remaining type II pneumocytes (Figure S1"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T35","span":{"begin":311,"end":315},"obj":"Body_part"}],"attributes":[{"id":"A35","pred":"uberon_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"ified subsets of epithelial cells expressing ACE2 and TMPRSS2 (Figure S1 ; Table S3; STAR Methods). The majority of ACE2 + TMPRSS2 + cells were, once again, type II pneumocytes (22%) and type I pneumocytes (9.7%) and were largely enriched within granulomatous regions compared with those in adjacent uninvolved lung (Figures S1B and S1C) (p = 0.006, Fisher Exact Test). ACE2 + TMPRSS2 + type II pneumocytes expressed significantly higher amounts of antimicrobial effectors such as LCN2 compared with remaining type II pneumocytes (Figure S1"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T106","span":{"begin":85,"end":89},"obj":"Disease"}],"attributes":[{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0010408"}],"text":"ified subsets of epithelial cells expressing ACE2 and TMPRSS2 (Figure S1 ; Table S3; STAR Methods). The majority of ACE2 + TMPRSS2 + cells were, once again, type II pneumocytes (22%) and type I pneumocytes (9.7%) and were largely enriched within granulomatous regions compared with those in adjacent uninvolved lung (Figures S1B and S1C) (p = 0.006, Fisher Exact Test). ACE2 + TMPRSS2 + type II pneumocytes expressed significantly higher amounts of antimicrobial effectors such as LCN2 compared with remaining type II pneumocytes (Figure S1"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T95036","span":{"begin":17,"end":27},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T34107","span":{"begin":28,"end":33},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2157","span":{"begin":70,"end":72},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T63441","span":{"begin":133,"end":138},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T39559","span":{"begin":178,"end":180},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T74853","span":{"begin":311,"end":315},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T2994","span":{"begin":311,"end":315},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T21425","span":{"begin":363,"end":367},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"text":"ified subsets of epithelial cells expressing ACE2 and TMPRSS2 (Figure S1 ; Table S3; STAR Methods). The majority of ACE2 + TMPRSS2 + cells were, once again, type II pneumocytes (22%) and type I pneumocytes (9.7%) and were largely enriched within granulomatous regions compared with those in adjacent uninvolved lung (Figures S1B and S1C) (p = 0.006, Fisher Exact Test). ACE2 + TMPRSS2 + type II pneumocytes expressed significantly higher amounts of antimicrobial effectors such as LCN2 compared with remaining type II pneumocytes (Figure S1"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T71","span":{"begin":81,"end":83},"obj":"Chemical"},{"id":"T72","span":{"begin":162,"end":164},"obj":"Chemical"},{"id":"T73","span":{"begin":392,"end":394},"obj":"Chemical"},{"id":"T74","span":{"begin":449,"end":462},"obj":"Chemical"},{"id":"T75","span":{"begin":515,"end":517},"obj":"Chemical"}],"attributes":[{"id":"A71","pred":"chebi_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"},{"id":"A72","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A73","pred":"chebi_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A74","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_33281"},{"id":"A75","pred":"chebi_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"}],"text":"ified subsets of epithelial cells expressing ACE2 and TMPRSS2 (Figure S1 ; Table S3; STAR Methods). The majority of ACE2 + TMPRSS2 + cells were, once again, type II pneumocytes (22%) and type I pneumocytes (9.7%) and were largely enriched within granulomatous regions compared with those in adjacent uninvolved lung (Figures S1B and S1C) (p = 0.006, Fisher Exact Test). ACE2 + TMPRSS2 + type II pneumocytes expressed significantly higher amounts of antimicrobial effectors such as LCN2 compared with remaining type II pneumocytes (Figure S1"}

{"project":"LitCovid-sentences","denotations":[{"id":"T106","span":{"begin":100,"end":369},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ified subsets of epithelial cells expressing ACE2 and TMPRSS2 (Figure S1 ; Table S3; STAR Methods). The majority of ACE2 + TMPRSS2 + cells were, once again, type II pneumocytes (22%) and type I pneumocytes (9.7%) and were largely enriched within granulomatous regions compared with those in adjacent uninvolved lung (Figures S1B and S1C) (p = 0.006, Fisher Exact Test). ACE2 + TMPRSS2 + type II pneumocytes expressed significantly higher amounts of antimicrobial effectors such as LCN2 compared with remaining type II pneumocytes (Figure S1"}

{"project":"LitCovid-PubTator","denotations":[{"id":"597","span":{"begin":45,"end":49},"obj":"Gene"},{"id":"598","span":{"begin":54,"end":61},"obj":"Gene"},{"id":"599","span":{"begin":116,"end":120},"obj":"Gene"},{"id":"600","span":{"begin":123,"end":130},"obj":"Gene"},{"id":"601","span":{"begin":370,"end":374},"obj":"Gene"},{"id":"602","span":{"begin":377,"end":384},"obj":"Gene"},{"id":"603","span":{"begin":481,"end":485},"obj":"Gene"},{"id":"610","span":{"begin":85,"end":89},"obj":"Gene"}],"attributes":[{"id":"A597","pred":"tao:has_database_id","subj":"597","obj":"Gene:102130864"},{"id":"A598","pred":"tao:has_database_id","subj":"598","obj":"Gene:102137447"},{"id":"A599","pred":"tao:has_database_id","subj":"599","obj":"Gene:102130864"},{"id":"A600","pred":"tao:has_database_id","subj":"600","obj":"Gene:102137447"},{"id":"A601","pred":"tao:has_database_id","subj":"601","obj":"Gene:102130864"},{"id":"A602","pred":"tao:has_database_id","subj":"602","obj":"Gene:102137447"},{"id":"A603","pred":"tao:has_database_id","subj":"603","obj":"Gene:3934"},{"id":"A610","pred":"tao:has_database_id","subj":"610","obj":"Gene:102132972"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ified subsets of epithelial cells expressing ACE2 and TMPRSS2 (Figure S1 ; Table S3; STAR Methods). The majority of ACE2 + TMPRSS2 + cells were, once again, type II pneumocytes (22%) and type I pneumocytes (9.7%) and were largely enriched within granulomatous regions compared with those in adjacent uninvolved lung (Figures S1B and S1C) (p = 0.006, Fisher Exact Test). ACE2 + TMPRSS2 + type II pneumocytes expressed significantly higher amounts of antimicrobial effectors such as LCN2 compared with remaining type II pneumocytes (Figure S1"}