Fig. 1 ACE-2 regulates blood pressure and volume, inflammation, diuresis, N+/K + balance, and protects organs (mainly lung, heart and liver) from fibrosis. It is a key cell transmembrane glycoprotein which prevents hypertension and protects from tissue injury by opposing the activation of the Renin Angiotensin Aldosterone System (RAAS), and the deleterious effects of Angiotensin II (AII) and Aldosterone. Through its binding to ACE2, SARS-CoV-2 infects cells, such as lung alveolar epithelial cells (where ACE-2 is highly expressed), and interferes in the RAAS, by impacting ACE-2 beneficial action. We hypothesize that binding of SARS-CoV-2 S Protein to ACE-2 could induce generation of allo- or/and autoantibodies.