PMC:7247521 / 5449-6439 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7247521","sourcedb":"PMC","sourceid":"7247521","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7247521","text":"QFPD contains a total of 21 traditional Chinese medicines, and it is difficult to elucidate the complex mechanism of QFPD on COVID-19 by traditional pharmacological methods due to the multi-components and multi-targets of the formula. Network pharmacology, a new method in recent years, can integrate interactions of drugs, targets, pathways and diseases into a biological network system [8]. Therefore, more and more TCM researchers have begun to use network pharmacology to explore the material basis of TCM, and to reveal the overall comprehensive effects of multi-path, multi-component and multi-target of TCM prescription and its treatment of diseases [9,10]. More importantly, previous study reported that disease conditions can be more fragile than health systems against various perturbations for the un-optimized system [11]. So the formula may be more effective for COVID-19 disease via the stronger effects on the reduction of the robustness of the COVID-19 disease network 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