Acknowledgement This work was supported by the 10.13039/100007219Shanghai Natural Science Foundation (17ZR1427600), National Science and Technology Major Projects for "Major New Drugs Innovation and Development" (2018ZX09201008-002-091 and 2018ZX09201008-002-092), Three-year Action Plan of "strong and excellent Chinese Medicine" in Hongkou District (HGY-MGB-2018-01-01), Shanghai Science and Technology Support Project in Biomedicine Field (18401932900), Budgetary Projects of Shanghai University of Traditional Chinese Medicine (2019LK046), Special Clinical Research Project of Health Profession of Shanghai Municipal Commission of Health (20194Y0081).