Interestingly, all the five FUs of QFPD showed higher disturbance score than negative control (BXTM), indicating that MSXG, SGMH, XCH, WLS and Others may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes (Cdc20, Ido1, Ifng, Il10, Il6, Ptger4, Spi1, Tnf) which were related to the bacterial and viral responses, cytokine, immune system, signaling transduction, etc.