−6.4 −6.3 −6.5 −6.8 −6.4 −6.6 Nsp16(2′-O-MTase) −8.1 −7.4 −7.6 −7.8 −7.8 −8.3 −7.7 −8.4 −8.2 N protein NCB site −8.1 −7.9 −8 −8 −7.6 −7.8 −7.5 −7.7 −7.9 E protein(ion channel) −6.4 −6.9 −7.2 −7.2 −6.9 −6.9 −7.9 −6.8 −6.8 M: MXSG, S: SGMH, X: XCH, O: Others. Next, to illustrate the mechanism of QFPD against COVID-19, a formula-attacked target-