Fourthly, the potential 201 target genes of SGMH were analyzed by PPI network, and the results showed that there were 153 nodes and 505 edges. 3 modules scores were > 2.5 (Fig. 5D). Module 1 (score: 3.529) consisted of 17 nodes and the seed gene was ACSS1; Module 2 (score: 4.5) consisted of 7 nodes and the seed gene was CNR2; module 3 (score: 3.5) consisted of 8 nodes and the seed gene was PRKCG. KEGG pathway enrichment analysis showed that SGMH modules were enriched in insulin resistance, adipocytokine signaling pathway, Th17 cell differentiation, et.al.