ID-19 injury by qingfei paidu decoction via anti-viral, anti-inflammatory activity and metabolic programming

Graphical abstract

Highlights
•  A novel FUNP analysis on QFPD function.
•  QFPD act on COVID-19 via anti-viral, anti-inflammatory and metabolic programming.
•  9 QFPD ingredients presented good molecular docking score for 2019-nCov.
•  SGMH, MXSG and Others are the top 3 efficient formula for COVID-19.

Abstract
Qingfei Paidu decoction (QFPD), a multi-component herbal formula, has been widely used to treat COVID-19 in China. However, its active compounds and mechanisms of action are still unknown. Firstly, we divided QFPD into five functional units (FUs) according to the compatibility theory of traditional Chinese medicine. The corresponding common targets of the five FUs were all significantly enriched in Go Ontology (oxidoreductase activity, lipid metabolic process, home