turbance scores are calculated according to the changes before and after drug intervention. Finally, the disturbance effect of the five formulae on the COVID-19 network was compared with null models with the total score of the disturbance, and the higher the value is, the higher the damage degree of drugs to the stability of the network is [12]. We take Banxia tianma baizhu decoction (BXTM) as negative control; and another efficient formula Yi du bi fei decoction (YDBF) as positive