In this study, we aimed to illustrate the existence of these fungal antigens from 181 patients with severe COVID-19 in at Hubei Provincial Hospital of Traditional Chinese Medicine (Wuhan, China) between December 31, 2019, and February 24, 2020., where was known for its severe outbreak of SARS-CoV-2. This study was approved by the ethics committee of Hubei Provincial Hospital of Traditional Chinese Medicine, and its protocols followed the Declaration of Helsinki.