MQRK and QARSEDKRA are predicted for Nsp8. • EDMLNPNYEDL and EFTPFDVVR epitopes are revealed for 3C-like proteinase. • Spike glycoprotein harbored one potential “VNNSYECDIPI” epitope. • A chimeric construct of the epitopes has high binding affinity for innate immune receptors. • Robust primary immune responses to the contrast are found. • Th