•  A novel multi-epitope based chimeric vaccine is designed for coronavirus disease (COVID-19).
•  Nsp8, 3C-like proteinase, and spike glycoprotein are potential targets for immune responses to COVID-19.
•  Two epitopes: DRDAAMQRK and QARSEDKRA are predicted for Nsp8.
•  EDMLNPNYEDL and EFTPFDVVR epitopes are revealed for 3C-like proteinase.
•  Spike glycoprotein harbored one potential “VNNSYECDIPI” epitope.
•  A chimeric construct of the epitopes has high binding affinity for innate immune receptors.
•  Robust primary immune responses to the contrast are found.
•  The construct-immune receptors complexes are dynamically stable.
•  Vigorous molecular mechanics and solvation energy were observed in the complexes.