Neutralizing antibodies (nAbs) can inhibit the viral infection via following the viral replication cycle. Attachment is the first critical step blocked by Abs by interfering with the virion-receptor binding. Moreover, Abs may induce the aggregation of viral particles which cause a reduction of individual penetration. In post-attachment step, Abs on the virion possibly dampen virus endocytosis internalization leading to the lysosomal degradation. The Abs also block fusion of virion when they intercalate between viruses and cell membrane. The next stage of interference is to uncoat or appropriate intracellular localization of core or capsid. Lastly, Abs might bind virion surface then inhibit the metabolic events that blocks the replication of viruses even after internalization [3,5,6].