It has been reported that the expression of ACE2 reduces with the increasing age. Since young patients possess high levels of ACE2, they are more prone to COVID-19 infection. Whereas, in old age people other than reduced ACE2 levels, other co-morbid conditions such as cardiovascular problems, diabetes, and hypertension might be present. The medication prescribed for these patients helps in elevating the ACE2 levels, which might enhance the viral entry. Though the treatment reduces the co-morbid severities, the viral infection is enhanced in those patients. Therefore, it is conclusive that young patients, even though they are more susceptible to the COVID-19 infection, they are less severely affected and exhibit elevated angiotensin II signaling. Whereas, the older patients who exhibit low levels of ACE2 and higher angiotensin II signaling leads to hypertension. The usage of ACEi and ARBs help in promoting the vasodilatory effects by elevating the ACE2 levels, thereby becoming susceptible to COVID-19 infection and are severely affected [130].