Unique considerations in those with HBV and HCV infections involve possible precautions for HBV and HCV therapies in those with or without SARS‐CoV‐2 infection and COVID‐19 manifestations of abnormalities in hepatic biochemical tests (Fig. 1). As per the American Association for the Study of Liver Diseases guidance document, it would seem reasonable to initiate HCV therapy, in newly diagnosed cases of HCV, in those without a SARS‐CoV‐2 infection if adequate resources are available and if those resources have not been deployed for COVID‐19 activities (e.g., pharmacy services, personnel for approval of therapy, blood testing service, follow‐up facilities through telemedicine or face‐to‐face). 18  In those with COVID‐19 in the background of a recently diagnosed HCV infection, it seems reasonable to defer HCV therapy until a time when COVID‐19 has cleared, whereas already initiated therapy can be continued while monitoring for DDIs. In those patients with HBV, it is important to be aware of the risk for HBV reactivation related to medications, such as tocilizumab and corticosteroids, used in the context of COVID‐19. Reactivation of HBV following the use of tocilizumab and prednisone has been described, and thus prophylaxis against HBV reactivation should be a consideration. 19 ,  20  In addition, chronic HBV therapy where indicated as per guidelines 21  can be initiated in those with newly diagnosed HBV and continued if receiving therapy, regardless of COVID‐19. Last but not least, caution needs to be exercised in initiating COVID‐19‐related therapy in those with advanced liver disease; thus, established guidelines on such use need to be followed to minimize the risk for hepatic decompensation, although the risk/benefit of an intervention is likely to weigh in heavily in dealing with the highly lethal condition of COVID‐19.