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PMC:7228307 / 34394-35230 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 794-800 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
602 62-67 Gene denotes FcγRI Gene:2214
603 79-86 Gene denotes FcγRIII Gene:2214
604 734-742 Gene denotes FcγRIIIa Gene:2214
605 69-75 Gene denotes FcγRII Gene:2214
606 610-614 Gene denotes FcγR Gene:2213
607 206-210 Gene denotes FcγR Gene:2213
608 33-38 Species denotes human Tax:9606
609 404-419 Chemical denotes N‐linked glycan
610 423-433 Chemical denotes asparagine MESH:D001216
611 439-443 Chemical denotes N297
612 794-800 Chemical denotes fucose MESH:D005643
613 818-833 Chemical denotes oligosaccharide MESH:D009844

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T332 513-516 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T333 713-716 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T334 794-800 Body_part denotes fucose http://purl.org/sig/ont/fma/fma82790
T335 818-833 Body_part denotes oligosaccharide http://purl.org/sig/ont/fma/fma82742

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T664 33-38 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T665 44-46 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T666 62-64 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T667 69-71 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T668 79-81 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T669 206-208 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T670 517-519 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T671 610-612 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T672 734-736 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T673 815-817 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T186 65-67 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T188 378-380 Chemical denotes FG http://purl.obolibrary.org/obo/CHEBI_73635
T189 423-433 Chemical denotes asparagine http://purl.obolibrary.org/obo/CHEBI_22653
T190 794-800 Chemical denotes fucose http://purl.obolibrary.org/obo/CHEBI_33984
T191 818-833 Chemical denotes oligosaccharide http://purl.obolibrary.org/obo/CHEBI_50699

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T37 423-433 Chemical denotes asparagine http://purl.obolibrary.org/obo/CHEBI_22653
T38 794-800 Chemical denotes fucose http://purl.obolibrary.org/obo/CHEBI_33984
T39 818-833 Chemical denotes oligosaccharide http://purl.obolibrary.org/obo/CHEBI_50699

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
602 62-67 Gene denotes FcγRI Gene:2214
603 79-86 Gene denotes FcγRIII Gene:2214
604 734-742 Gene denotes FcγRIIIa Gene:2214
605 69-75 Gene denotes FcγRII Gene:2214
606 610-614 Gene denotes FcγR Gene:2213
607 206-210 Gene denotes FcγR Gene:2213
608 33-38 Species denotes human Tax:9606
609 404-419 Chemical denotes N‐linked glycan
610 423-433 Chemical denotes asparagine MESH:D001216
611 439-443 Chemical denotes N297
612 794-800 Chemical denotes fucose MESH:D005643
613 818-833 Chemical denotes oligosaccharide MESH:D009844

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T40 33-38 Species denotes human NCBItxid:9606

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T197 0-166 Sentence denotes Crystallographic analyses of the human IgG1‐Fc complexed with FcγRI, FcγRII or FcγRIII show that these interactions are similar in topology, and asymmetric in nature.
T198 167-248 Sentence denotes The second extracellular domain of the FcγR inserts between the two heavy chains.
T199 249-399 Sentence denotes Here it makes contacts with the lower hinge of both H chains and with residues of the adjacent BC loop of one CH2 domain and the FG loop of the other.
T200 400-581 Sentence denotes The N‐linked glycan at asparagine 297 (N297) of the heavy chain is essential for the structural integrity of the IgG‐Fc by affecting the spacing and conformation of the CH2 domains.
T201 582-836 Sentence denotes Indeed, its removal ablates FcγR binding.67 Of particular relevance to therapeutic mAb development is that the normal low‐affinity IgG interaction with FcγRIIIa is profoundly increased by the removal of the core fucose from the N297 Fc oligosaccharide.68

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T331 513-516 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T332 713-716 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T333 794-800 Body_part denotes fucose http://purl.org/sig/ont/fma/fma82790
T334 818-833 Body_part denotes oligosaccharide http://purl.org/sig/ont/fma/fma82742

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T197 0-166 Sentence denotes Crystallographic analyses of the human IgG1‐Fc complexed with FcγRI, FcγRII or FcγRIII show that these interactions are similar in topology, and asymmetric in nature.
T198 167-248 Sentence denotes The second extracellular domain of the FcγR inserts between the two heavy chains.
T199 249-399 Sentence denotes Here it makes contacts with the lower hinge of both H chains and with residues of the adjacent BC loop of one CH2 domain and the FG loop of the other.
T200 400-581 Sentence denotes The N‐linked glycan at asparagine 297 (N297) of the heavy chain is essential for the structural integrity of the IgG‐Fc by affecting the spacing and conformation of the CH2 domains.
T201 582-836 Sentence denotes Indeed, its removal ablates FcγR binding.67 Of particular relevance to therapeutic mAb development is that the normal low‐affinity IgG interaction with FcγRIIIa is profoundly increased by the removal of the core fucose from the N297 Fc oligosaccharide.68