•  Emergence of the new coronavirus, SARS-CoV-2 has led to a global pandemic disease
•  Hydroxychloroquine/azithromycin combination therapy is currently being tested
•  Molecular mimicry between azithromycin and ganglioside sugar is revealed
•  Azithromycin binds to the virus spike protein of SARS-CoV-2 and hydroxychloroquine binds to gangliosides
•  Hydroxychloroquine/azithromycin have synergistic effect against SARS-CoV-2 infection